Skip to main content

Table 3 Cross-lagged path coefficients between log-transformed hsCRP and HOMA-IR by glycemia status, race, sex, and follow-up period

From: Temporal relationship between inflammation and insulin resistance and their joint effect on hyperglycemia: the Bogalusa Heart Study

 

Path coefficients

Goodness-of-fit

HOMA-IR → hsCRP

hsCRP → HOMA-IR

pa

RMR

CFI

β1

p

β2

p

Glycemia status

 Normoglycemia (n = 278)

− 0.037

0.483

0.081

0.155

0.032

0.022

0.990

 Hyperglycemia (n = 231)

0.045

0.449

0.156

0.008

0.059

0.054

0.914

 T2DM (n = 68)

0.131

0.206

0.143

0.199

0.911

0.031

0.994

 Pre-T2DM (n = 163)

0.006

0.938

0.177

0.012

0.015

0.061

0.884

 pb

0.141

 

0.194

    

 pc

0.011

 

0.380

    

 pd

0.475

 

0.121

    

Race

 White (n = 360)

0.029

0.530

0.108

0.023

0.111

0.097

0.932

 Black (n = 149)

− 0.052

0.490

0.120

0.117

0.022

0.148

1.000

 pe

0.148

 

0.843

    

Sex

 Male (n = 176)

0.013

0.848

0.044

0.518

0.645

0.104

0.928

 Female (n = 333)

− 0.001

0.986

0.138

0.006

0.005

0.111

0.962

 pf

0.801

 

0.095

    

Follow-up period

 Below median (n = 245)

− 0.018

0.756

0.035

0.560

0.352

0.067

0.862

 Above median (n = 264)

0.026

0.627

0.199

< 0.001

< 0.001

0.002

0.981

 pg

0.885

 

0.003

    
  1. β, standardized regression coefficient; RMR, root mean square residual; CFI, comparative fit index; hsCRP, high-sensitivity C-reactive protein; HOMA-IR, homeostasis model assessment for insulin resistance; T2DM, type 2 diabetes mellitus
  2. ap value for difference between β1 and β2
  3. bp value for difference in β1 and β2 between hyperglycemia and normoglycemia groups
  4. cp value for difference in β1 and β2 between T2DM and normoglycemia groups
  5. dp value for difference in β1 and β2 between pre-T2DM and normoglycemia groups
  6. ep value for difference in β1 and β2 between whites and blacks
  7. fp value for difference in β1 and β2 between males and females
  8. gp value for difference in β1 and β2 between follow-up period groups (median = 6.7 years)
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840