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Table 3 Cross-lagged path coefficients between log-transformed hsCRP and HOMA-IR by glycemia status, race, sex, and follow-up period

From: Temporal relationship between inflammation and insulin resistance and their joint effect on hyperglycemia: the Bogalusa Heart Study

  Path coefficients Goodness-of-fit
HOMA-IR → hsCRP hsCRP → HOMA-IR pa RMR CFI
β1 p β2 p
Glycemia status
 Normoglycemia (n = 278) − 0.037 0.483 0.081 0.155 0.032 0.022 0.990
 Hyperglycemia (n = 231) 0.045 0.449 0.156 0.008 0.059 0.054 0.914
 T2DM (n = 68) 0.131 0.206 0.143 0.199 0.911 0.031 0.994
 Pre-T2DM (n = 163) 0.006 0.938 0.177 0.012 0.015 0.061 0.884
 pb 0.141   0.194     
 pc 0.011   0.380     
 pd 0.475   0.121     
Race
 White (n = 360) 0.029 0.530 0.108 0.023 0.111 0.097 0.932
 Black (n = 149) − 0.052 0.490 0.120 0.117 0.022 0.148 1.000
 pe 0.148   0.843     
Sex
 Male (n = 176) 0.013 0.848 0.044 0.518 0.645 0.104 0.928
 Female (n = 333) − 0.001 0.986 0.138 0.006 0.005 0.111 0.962
 pf 0.801   0.095     
Follow-up period
 Below median (n = 245) − 0.018 0.756 0.035 0.560 0.352 0.067 0.862
 Above median (n = 264) 0.026 0.627 0.199 < 0.001 < 0.001 0.002 0.981
 pg 0.885   0.003     
  1. β, standardized regression coefficient; RMR, root mean square residual; CFI, comparative fit index; hsCRP, high-sensitivity C-reactive protein; HOMA-IR, homeostasis model assessment for insulin resistance; T2DM, type 2 diabetes mellitus
  2. ap value for difference between β1 and β2
  3. bp value for difference in β1 and β2 between hyperglycemia and normoglycemia groups
  4. cp value for difference in β1 and β2 between T2DM and normoglycemia groups
  5. dp value for difference in β1 and β2 between pre-T2DM and normoglycemia groups
  6. ep value for difference in β1 and β2 between whites and blacks
  7. fp value for difference in β1 and β2 between males and females
  8. gp value for difference in β1 and β2 between follow-up period groups (median = 6.7 years)