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Table 3 Effects of add-on dapagliflozin therapy on home blood pressure profile

From: Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on albuminuria in Japanese patients with type 2 diabetes study (Y-AIDA study)

 

Baseline

Week 24

P value

Morning

 SBP (mmHg)

137.6 ± 14.5

129.7 ± 14.8

P < 0.001

 SBP-SD (mmHg)

8.8 ± 4.7

7.9 ± 3.8

P = 0.0496

 DBP (mmHg)

82.7 ± 10.3

78.7 ± 10.7

P < 0.001

 DBP-SD (mmHg)

5.2 ± 3.4

4.9 ± 3.0

P = 0.1494

 PR (beats/min)

72.9 ± 10.6

71.4 ± 10.8

P = 0.0785

Evening

 SBP (mmHg)

136.1 ± 17.4

127.2 ± 14.1

P < 0.001

 SBP-SD (mmHg)

9.4 ± 5.0

8.4 ± 4.0

P = 0.0143

 DBP (mmHg)

79.3 ± 10.1

75.0 ± 10.7

P < 0.001

 DBP-SD (mmHg)

5.7 ± 3.1

5.0 ± 2.5

P = 0.1331

 PR (beats/min)

76.5 ± 11.3

75.1 ± 11.0

P = 0.0414

Nocturnal

 SBP (mmHg)

125.4 ± 14.7

123.5 ± 15.1

P = 0.0079

 SBP-SD (mmHg)

8.9 ± 4.2

7.3 ± 3.2

P = 0.0049

 DBP (mmHg)

74.1 ± 9.5

72.8 ± 10.2

P = 0.0415

 DBP-SD (mmHg)

5.6 ± 2.8

4.7 ± 2.2

P = 0.0092

 PR (beats/min)

67.6 ± 11.2

65.6 ± 10.3

P = 0.0260

  1. Values are mean ± standard deviation (SD)
  2. SBP systolic blood pressure, DBP diastolic blood pressure, PR pulse rate