| Baseline | Week 8 | Week 16 | Week 24 |
---|---|---|---|---|
BW (kg) | 73.9 ± 16.6 | 72.5 ± 16.5**** | 72.2 ± 16.6**** | 72.1 ± 16.6**** |
BMI (kg/m2) | 27.1 ± 4.5 | 26.6 ± 4.5**** | 26.6 ± 4.6**** | 26.5 ± 4.6**** |
Office | ||||
 SBP (mmHg) | 142.2 ± 18.9 | 137.6 ± 18.4* | 136.8 ± 18.3* | 137.3 ± 19.0* |
 DBP (mmHg) | 79.0 ± 12.0 | 77.7 ± 12.7 | 77.3 ± 11.3 | 75.9 ± 11.4* |
 PR (bpm) | 82.9 ± 14.2 | 82.6 ± 14.5 | 82.0 ± 13.0 | 81.1 ± 12.7 |
 PP (mmHg) | 63.2 ± 18.2 | 59.9 ± 15.6* | 59.5 ± 17.0* | 61.4 ± 19.0 |
 MAP (mmHg) | 100.0 ± 11.8 | 97.6 ± 12.9 | 97.1 ± 11.5* | 96.3 ± 11.3* |
 Double product (bpm × mmHg) | 11,949.9 ± 2862.8 | 11,431.8 ± 2648.7* | 11,309.1 ± 2493.0* | 11,169.4 ± 2534.7** |
FBS (mg/dL) | 156.9 ± 38.4 | 143.3 ± 40.9*** | 142.0 ± 36.9*** | 141.1 ± 42.9*** |
HbA1c (%) | 7.8 ± 0.7 | 7.4 ± 0.7**** | 7.4 ± 0.7**** | 7.3 ± 0.7**** |
LDL (mg/dL) | 102.0 ± 29.0 | N/A | N/A | 102.4 ± 31.0 |
HDL (mg/dL) | 52.7 ± 15.4 | N/A | N/A | 54.1 ± 14.9 |
T. chol (mg/dL) | 184.4 ± 37.5 | N/A | N/A | 185.0 ± 35.8 |
TG (mg/dL) | 173.8 ± 115.1 | N/A | N/A | 177.5 ± 130.4 |
AST (U/L) | 28.3 ± 12.8 | 25.7 ± 8.9*** | 24.8 ± 8.5**** | 24.1 ± 8.1**** |
ALT (U/L) | 33.4 ± 19.5 | 28.2 ± 14.8**** | 27.1 ± 16.2**** | 25.7 ± 14.0**** |
ALP (U/L) | 235.0 ± 77.4 | 226.6 ± 73.5** | 221.4 ± 71.6**** | 221.5 ± 69.2**** |
γGTP (U/L) | 47.4 ± 34.5 | 39.4 ± 28.6**** | 38.5 ± 29.0**** | 37.0 ± 25.2**** |
WBC (/mm3) | 7289.8 ± 1930.2 | 7468.1 ± 1991.5 | 7339.3 ± 1767.2 | 7182.5 ± 1699.9 |
Plt (× 104/mm3) | 22.4 ± 6.4 | 22.7 ± 6.6 | 22.6 ± 6.5 | 22.3 ± 6.5 |