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Table 2 Effects of add-on dapagliflozin therapy on physical findings, arterial stiffness, glycolipid metabolism, liver function, and pro-inflammatory markers

From: Improved home BP profile with dapagliflozin is associated with amelioration of albuminuria in Japanese patients with diabetic nephropathy: the Yokohama add-on inhibitory efficacy of dapagliflozin on albuminuria in Japanese patients with type 2 diabetes study (Y-AIDA study)

  Baseline Week 8 Week 16 Week 24
BW (kg) 73.9 ± 16.6 72.5 ± 16.5**** 72.2 ± 16.6**** 72.1 ± 16.6****
BMI (kg/m2) 27.1 ± 4.5 26.6 ± 4.5**** 26.6 ± 4.6**** 26.5 ± 4.6****
Office
 SBP (mmHg) 142.2 ± 18.9 137.6 ± 18.4* 136.8 ± 18.3* 137.3 ± 19.0*
 DBP (mmHg) 79.0 ± 12.0 77.7 ± 12.7 77.3 ± 11.3 75.9 ± 11.4*
 PR (bpm) 82.9 ± 14.2 82.6 ± 14.5 82.0 ± 13.0 81.1 ± 12.7
 PP (mmHg) 63.2 ± 18.2 59.9 ± 15.6* 59.5 ± 17.0* 61.4 ± 19.0
 MAP (mmHg) 100.0 ± 11.8 97.6 ± 12.9 97.1 ± 11.5* 96.3 ± 11.3*
 Double product (bpm × mmHg) 11,949.9 ± 2862.8 11,431.8 ± 2648.7* 11,309.1 ± 2493.0* 11,169.4 ± 2534.7**
FBS (mg/dL) 156.9 ± 38.4 143.3 ± 40.9*** 142.0 ± 36.9*** 141.1 ± 42.9***
HbA1c (%) 7.8 ± 0.7 7.4 ± 0.7**** 7.4 ± 0.7**** 7.3 ± 0.7****
LDL (mg/dL) 102.0 ± 29.0 N/A N/A 102.4 ± 31.0
HDL (mg/dL) 52.7 ± 15.4 N/A N/A 54.1 ± 14.9
T. chol (mg/dL) 184.4 ± 37.5 N/A N/A 185.0 ± 35.8
TG (mg/dL) 173.8 ± 115.1 N/A N/A 177.5 ± 130.4
AST (U/L) 28.3 ± 12.8 25.7 ± 8.9*** 24.8 ± 8.5**** 24.1 ± 8.1****
ALT (U/L) 33.4 ± 19.5 28.2 ± 14.8**** 27.1 ± 16.2**** 25.7 ± 14.0****
ALP (U/L) 235.0 ± 77.4 226.6 ± 73.5** 221.4 ± 71.6**** 221.5 ± 69.2****
γGTP (U/L) 47.4 ± 34.5 39.4 ± 28.6**** 38.5 ± 29.0**** 37.0 ± 25.2****
WBC (/mm3) 7289.8 ± 1930.2 7468.1 ± 1991.5 7339.3 ± 1767.2 7182.5 ± 1699.9
Plt (× 104/mm3) 22.4 ± 6.4 22.7 ± 6.6 22.6 ± 6.5 22.3 ± 6.5
  1. Values are mean ± standard deviation (SD)
  2. BW body weight, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, PR pulse rate, PP pulse pressure, MAP mean arterial pressure, bpm beat per minute, FBS fasting blood sugar, HbA1c glycated hemoglobin, LDL low-density lipoprotein, HDL high-density lipoprotein, T. chol total cholesterol, TG triglyceride, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, γ-GTP γ-glutamyl transpeptidase, WBC white blood cell, Plt platelet, N/A not available
  3. *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001 versus baseline