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Table 2 Crude and adjusted HRs of cardiovascular outcomes and all-cause mortality

From: Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study

Outcome Number of severe hypoglycemia N Event Incidence rate (per 1000 patient-years) HR (95% CI) P for trend
Crude Sex- and age adjusted Multivariablea
Myocardial infarction 0 1,548,437 58,529 6.7 Reference Reference Reference < 0.001
1 15,992 945 12.1 2.36 (2.21–2.51) 1.83 (1.72–1.96) 1.56 (1.46–1.64)  
2 2543 182 16.1 3.12 (2.70–3.61) 2.31 (1.99–2.67) 1.86 (1.61–2.15)  
3 or more 1125 72 15.5 2.99 (2.97–3.77) 2.39 (1.90–3.01) 1.86 (1.48–2.35)  
Stroke 0 1,548,437 58,529 6.7 Reference Reference Reference < 0.001
1 15,992 1304 16.9 2.53 (2.40–2.67) 1.78 (1.68–1.88) 1.54 (1.46–1.63)  
2 2543 228 20.2 3.03 (2.66–3.45) 1.97 (1.73–2.24) 1.62 (1.42–1.84)  
3 or more 1125 115 24.9 3.74 (3.11–4.49) 2.69 (2.25–3.24) 2.14 (1.78–2.57)  
Heart failure 0 1,548,437 52,485 6.0 Reference Reference Reference < 0.001
1 15,992 1423 18.4 3.13 (2.97–3.30) 2.09 (1.99–2.21) 1.68 (1.60–1.78)  
2 2543 283 25.2 4.33 (3.85–4.87) 2.66 (2.36–2.99) 2.00 (1.78–2.25)  
3 or more 1125 139 30.5 5.31 (4.49–6.27) 3.65 (3.09–4.31) 2.59 (2.19–3.06)  
All-cause death 0 1,548,437 146,332 16.5 Reference Reference Reference < 0.001
1 15,992 5058 63.3 3.88 (3.77–3.99) 2.46 (2.39–2.53) 1.98 (1.93–2.04)  
2 2543 1074 91.6 5.63 (5.31–3.98) 3.24 (3.05–3.44) 2.39 (2.25–2.53)  
3 or more 1125 572 119.0 7.37 (6.79–8.00) 4.73 (4.35–5.13) 3.28 (3.02–3.56)  
  1. aAdjusted for age, sex, living place (urban or rural), income level, anti-diabetic drugs, the presence of hypertension, dyslipidemia, and major comorbidities (malignancy, liver cirrhosis, ESRD, and COPD)