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Table 4 Sensitivity analysis of the association between rs9267551 and MI in the two study samples

From: A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients

Study samples

DDAH2 rs9267551 genotype

Additive model

CZ (n = 1017)

GG

GC

CC

OR (95% CI)

p

MI-neg (n = 840)

757 (90.1%)

79 (9.4%)

4 (0.5%)

0.338 (0.144–0.793)

0.013a

 

0.293 (0.101–0.850)

0.024b

MI-pos (n = 177)

170 (96.0%)

7 (4.0%)

0 (0%)

0.350 (0.113–1.0.82)

0.068c

GHS (n = 755)

GG

GC

CC

OR (95% CI)

p

M-neg (n = 571)

499 (87.4%)

69 (12.1%)

3 (0.5%)

0.479 (0.256–0.899)

0.022a

 

0.487 (0.257–0.925)

0.028b

MI-pos (n = 184)

172 (93.5%)

12 (6.5%)

0 (0%)

0.454 (0.231–0.891)

0.022c

Pooled (n = 1772)

GG

GC

CC

OR (95% CI)

p

MI-neg (n = 1411)

1256 (89.0%)

148 (10.5%)

7 (0.5%)

0.429 (0.260–0.710)

0.001d

 

0.434 (0.251–0.748)

0.003e

MI-pos (n = 361)

342 (94.7%)

19 (5.3%)

0 (0%)

0.432 (0.243–0.766)

0.004f

  1. CZ Catanzaro Study, GHS Gargano Heart Study
  2. aAdjusted for sex, age, BMI, smoking habit
  3. bAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol and triglycerides levels
  4. cAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration and therapies
  5. dAdjusted for sex, age, BMI, smoking habit and study center
  6. eAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels and study center
  7. fAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration, therapies and study center