Skip to main content

Advertisement

Table 4 Sensitivity analysis of the association between rs9267551 and MI in the two study samples

From: A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients

Study samples DDAH2 rs9267551 genotype Additive model
CZ (n = 1017) GG GC CC OR (95% CI) p
MI-neg (n = 840) 757 (90.1%) 79 (9.4%) 4 (0.5%) 0.338 (0.144–0.793) 0.013a
  0.293 (0.101–0.850) 0.024b
MI-pos (n = 177) 170 (96.0%) 7 (4.0%) 0 (0%) 0.350 (0.113–1.0.82) 0.068c
  1. CZ Catanzaro Study, GHS Gargano Heart Study
  2. aAdjusted for sex, age, BMI, smoking habit
  3. bAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol and triglycerides levels
  4. cAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration and therapies
  5. dAdjusted for sex, age, BMI, smoking habit and study center
  6. eAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels and study center
  7. fAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration, therapies and study center
GHS (n = 755) GG GC CC OR (95% CI) p
M-neg (n = 571) 499 (87.4%) 69 (12.1%) 3 (0.5%) 0.479 (0.256–0.899) 0.022a
  0.487 (0.257–0.925) 0.028b
MI-pos (n = 184) 172 (93.5%) 12 (6.5%) 0 (0%) 0.454 (0.231–0.891) 0.022c
  1. CZ Catanzaro Study, GHS Gargano Heart Study
  2. aAdjusted for sex, age, BMI, smoking habit
  3. bAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol and triglycerides levels
  4. cAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration and therapies
  5. dAdjusted for sex, age, BMI, smoking habit and study center
  6. eAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels and study center
  7. fAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration, therapies and study center
Pooled (n = 1772) GG GC CC OR (95% CI) p
MI-neg (n = 1411) 1256 (89.0%) 148 (10.5%) 7 (0.5%) 0.429 (0.260–0.710) 0.001d
  0.434 (0.251–0.748) 0.003e
MI-pos (n = 361) 342 (94.7%) 19 (5.3%) 0 (0%) 0.432 (0.243–0.766) 0.004f
  1. CZ Catanzaro Study, GHS Gargano Heart Study
  2. aAdjusted for sex, age, BMI, smoking habit
  3. bAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol and triglycerides levels
  4. cAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration and therapies
  5. dAdjusted for sex, age, BMI, smoking habit and study center
  6. eAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels and study center
  7. fAdjusted for sex, age, BMI, smoking habit, HbA1c, total cholesterol, HDL cholesterol, triglycerides levels, diabetes duration, therapies and study center