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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Class effects of SGLT2 inhibitors on cardiorenal outcomes

Fig. 3

Composite renal outcome rates in the Dapagliflozin Effect on CardiovascuLAR Events (DECLARE-TIMI 58), CANagliflozin CardioVascular Assessment Study (CANVAS) Program, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients–Removing Excess Glucose (EMPA–REG OUTCOME), and Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trials. Statistical outcomes displayed as hazard ratio, 95% confidence interval, p-value. Composite renal outcomes defined as follows: DECLARE-TIMI 58: ≥ 40% reduction in estimated glomerular filtration rate (eGFR) to < 60, end-stage renal disease (ESRD) (dialysis ≥ 90 days, transplant or sustained eGFR < 15), or renal/cardiovascular (CV) death; CANVAS: ≥ 40% reduction in eGFR, renal-replacement therapy (RRT) (transplant, chronic dialysis, or sustained eGFR < 15), or renal death; EMPA–REG OUTCOME: doubling of serum creatinine (Cr) with eGFR ≤ 45, RRT, or renal death; CREDENCE: doubling of serum Cr, ESRD (eGFR < 15, dialysis, or renal transplant), renal/CV death. HR hazard ratio, DAPA dapagliflozin, CANA canagliflozin, EMPA empagliflozin

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