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Table 1 Characteristics of included studies

From: Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis

Author

Year

Study design

Gender male %

Age

Sample size

Follow-up (y)

Country

Patient

The NOS for assessing the quality of studies

Selection

Comparability

Exposure

Abualsuod [21]

2015

Retrospective cohort

52%

60.42 (13.36)

720

1

USA

MI + T2DM

☆☆☆

☆

☆☆☆

Al Ali [22]

2016

RCT

81%

57.9 (11.4)

237

0.3

Netherlands

MI-T2DM

☆☆☆☆

☆☆

☆☆

Basnet [23]

2015

Case control

65%

–

274

0.0

USA

MI + T2DM

☆☆☆

☆

☆☆

Chen [24]

2016

Retrospective cohort

53%

52.53 (10.07)

179,742

0.3

Canada

T2DM

☆☆☆

☆

☆☆

Duncan [25]

2007

Retrospective cohort

76%

65 (58–72)

1284

0.0

USA

CVD + T2DM

☆☆☆☆

☆

☆☆

Eppinga [26]

2016

RCT

75%

58.80 (11.82)

371

0.3

Netherlands

MI-T2DM

☆☆☆☆

☆☆

☆☆☆

Evans [27]

2006

Retrospective cohort

51%

60.2

7967

5.0

UK

T2DM

☆☆☆☆

☆☆

☆☆☆

Facila [28]

2017

RCT

56%

71 (10)

835

2.4

Spain

HF + T2DM

☆☆☆

☆☆

☆☆☆

Fung [29]

2015

Retrospective cohort

40%

61.70 (10.75)

11,293

5.0

China

T2DM

☆☆☆☆

☆

☆☆☆

Hartman [30]

2017

RCT

–

–

379

2.0

Netherlands

MI-T2DM

☆☆☆☆

☆☆

☆☆☆

Hong [31]

2013

RCT

78%

62.8 (8.5)

304

5.0

China

CVD + T2DM

☆☆☆☆

☆☆

☆☆☆

Johnson [32]

2005

Retrospective cohort

52%

64.3 (12.4)

4142

9.0

Canada

T2DM

☆☆☆

☆

☆☆☆

Jong [16]

2019

Retrospective cohort

74%

65.9 (10.8)

636

2.0

Taiwan

MI + T2DM

☆☆☆

☆

☆☆

Kitao [33]

2017

RCT

65%

60 (20–74)

96

0.3

Japan

T2DM-CVD

☆☆☆☆

☆☆

☆☆

Kooy [34]

2009

RCT

41%

64 (10)

390

4.0

Netherlands

T2DM

☆☆☆☆

☆☆

☆☆☆

Kruszelnicka [35]

2015

Case control

60%

67 (8)

70

0.0

Poland

CVD + T2DM

☆☆☆

☆

☆☆

Lexis [36]

2012

RCT

–

–

350

0.8–10.7

Netherlands

MI-T2DM

☆☆☆☆

☆☆

☆☆☆

Lexis [37]

2014

Retrospective cohort

64%

66 (12)

3948

0.3

Netherlands

MI + T2DM

☆☆☆

☆

☆

Lexis [38]

2015

RCT

77%

58.1 (11.9)

346

0.4

Netherlands

MI-T2DM

☆☆☆☆

☆☆

☆☆

Lexis [39]

2014a

RCT

75%

58.7 (11.8)

379

0.3

Netherlands

MI-T2DM

☆☆☆☆

☆☆

☆☆

Li [40]

2014

RCT

68%

62.4 (11.0)

152

1.0

China

T2DM

☆☆☆☆

☆

☆☆

Liu [41]

2016

Retrospective cohort

44%

60.7

272,149

7.4

USA

T2DM

☆☆

☆

☆

Liu [42]

2017

RCT

47%

59 (17)

60

0.5

China

CVD + T2DM

☆☆☆

☆

☆

Morgan [43]

2014

Retrospective cohort

36%

66.6 (10.4)

5208

0.0

UK

T2DM

☆☆☆☆

☆☆

☆☆☆

Pantalone [44]

2009

Retrospective cohort

42%

56.8 (13.9)

20,450

n

USA

T2DM-CVD

☆☆☆

☆

☆☆☆

Preiss [45]

2014

RCT

81%

63 (8)

173

1.5

UK

CVD-T2DM

☆☆☆☆

☆☆

☆☆☆

Rachmani [46]

2002

RCT

53%

65 (4)

393

4.0

Israel

T2DM

☆☆

☆☆

☆☆

Raee [47]

2017

Retrospective cohort

42%

55 (11.1)

717

13.6

Iran

T2DM

☆☆☆☆

☆

☆☆

Retwiński [48]

2018

Retrospective cohort

70%

64.5 (10.5)

1030

1.0

Poland

HF + T2DM

☆☆☆☆

☆

☆☆☆

Romero [49]

2013

Retrospective cohort

47%

70.5 (7.0)

1184

9.0

Spain

HF + T2DM

☆☆☆☆

☆

☆☆☆

Roumie [50]

2012

Retrospective cohort

97%

65 (57–74)

161,296

5.0

USA

T2DM

☆☆☆☆

☆☆

☆☆☆

Roumie [51]

2017

Retrospective cohort

97%

66 (57–75)

131,972

7.5

USA

T2DM

☆☆☆☆

☆☆

☆☆☆

Roussel [52]

2010

Retrospective cohort

66%

67.1 (9.3)

19,691

2.0

France

T2DM

☆☆☆☆

☆

☆☆☆

Scheller [53]

2014

Retrospective cohort

52%

59.0 (15.2)

84,756

4.0

Denmark

T2DM

☆☆☆☆

☆☆

☆☆☆

Schramm [54]

2011

Retrospective cohort

51%

52.5 (14.0)

110,374

9.0

Denmark

T2DM

☆☆☆☆

☆

☆☆☆

Shah [55]

2010

Retrospective cohort

79%

56 (11)

131

2.0

USA

HF + T2DM

☆☆☆

☆

☆☆☆

Sillars [56]

2010

Retrospective cohort

44%

60.6 (11.9)

1271

15.0

Australia

T2DM

☆☆☆

☆

☆☆☆

Wang [57]

2017

Retrospective cohort

–

72.49 (5.15)

41,204

8.0

USA

T2DM

☆☆☆

☆

☆☆☆

Wong [58]

2012

RCT

90%

64 (8)

62

0.3

UK

HF-T2DM

☆☆☆

☆☆

☆☆☆

Zeller [59]

2016

Case control

76%

61 (11)

372

0.0

France

MI + T2DM

☆☆☆

☆

☆☆

Total studies

40

   

1,066,408