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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Class effect for SGLT-2 inhibitors: a tale of 9 drugs

Fig. 3

Class effects for the cardiorenal outcomes of SGLT-2 inhibitors. A class effect is not evident for MACE (only three trials demonstrated a significant reduction of the MACE risk), but is evident for heart failure (reduced risk of hospitalization for heart failure) and DKD progression (reduced decline of eGFR, renal death, or requirement for renal replacement therapy). MACE, major cardiovascular events; DKD, diabetic kidney disease; EMP, EMPAREG-OUTCOME; CAN, CANVAS; DEC, DECLARE; CRE, CREDENCE

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