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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

Fig. 4

Accumulation of cardiac BCAAs in TAC mouse hearts. BT2 increases cardiac BCAA oxidation in mouse. Levels of cardiac BCAAs (n = 5/group) (a). Densitometry analysis of BCATm protein expression normalized to Tubulin (n = 6/group) (b). Schematic drawing of BT2 inhibition on BCAA catabolic pathway (c). Rates of BCAA oxidation in normal hearts perfused with BT2 (200 µM) (n = 4/group) (d). Rates of BCAA oxidation in normal hearts at 3 week post daily BT2 treatment (40 mg/kg/day) (Vehicle, n = 6; BT2 Inhibitor, n =) (e). Cardiac work for acute and chronic BT2 treatment was measured as a functional parameter during ex vivo working heart perfusion f and g respectively. Data are presented as mean ± SEM. Data were analysed by t-test. *p < 0.05 was considered statistically significant

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