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Table 3 Clinical parameters, metabolic factors and adipose tissue compartment changes from baseline after 26 weeks of treatment in the per-protocol analysis

From: A double-blind, placebo-controlled, randomised trial to assess the effect of liraglutide on ectopic fat accumulation in South Asian type 2 diabetes patients

Characteristic Mean ± SD change from baseline to 26 weeks Mean [95% CI] changes from baseline (liraglutide vs placebo) P value
Liraglutide (n = 20) Placebo (n = 24)
Clinical parameters
 Body weight (kg) − 4.3 ± 3.4 − 0.6 ± 2.2 − 4.0 [− 5.8, − 2.3] < 0.001
 BMI (kg/m2) − 1.6 ± 1.4 − 0.2 ± 0.9 − 1.5 [− 2.2, − 0.8] < 0.001
 Waist circumference (cm) − 5 ± 4 0 ± 4 − 5 [− 8, − 2] 0.001
 Hip circumference (cm) − 4 ± 5 − 2 ± 3 − 2 [− 5, 0] 0.068
 Waist-hip ratio − 0.01 ± 0.04 0.02 ± 0.05 − 0.01 [− 0.04, 0.02] 0.394
 Lean body mass (kg) − 2.4 ± 2.4 0.4 ± 3.0 − 2.8 [− 4.5, − 1.1] 0.002
 Lean body mass (%) 0.4 ± 1.6 0.8 ± 2.7 − 0.4 [− 1.8, 1.0] 0.605
Metabolic factors
 HbA1c (mmol/mol) − 10.5 ± 9.1 − 6.1 ± 8.8 − 6.5 [− 11.5, − 1.5] 0.011
 HbA1c (%) − 1.0 ± 0.8 − 0.6 ± 0.8 − 0.6 [− 1.1, − 0.1] 0.011
 Total cholesterol (mmol/L) 0.06 ± 0.98 − 0.37 ± 0.78 0.28 [− 0.26, 0.81] 0.305
 HDL-cholesterol (mmol/L) − 0.04 ± 0.12 − 0.06 ± 0.11 0.02 [− 0.05, 0.10] 0.510
 LDL-cholesterol (mmol/L) 0.04 ± 0.66 − 0.07 ± 0.68 0.08 [− 0.32, 0.48] 0.689
 Triglycerides (mmol/L) 0.12 ± 1.13 − 0.38 ± 1.32 0.13 [− 0.47, 0.74] 0.663
Adipose tissue compartments
 Subcutaneous AT (cm2) − 26 ± 38 − 11 ± 37 − 15 [− 38, 7] 0.182
 Visceral AT (cm2) − 23 ± 27 − 2 ± 17 − 17 [− 32, − 3] 0.020
 Epicardial AT (cm2) 0 ± 2 1 ± 1 − 1 [− 2, 0] 0.139
 Paracardial AT (cm2) − 1 ± 3 0 ± 3 − 1 [− 3, 1] 0.467
 Hepatic TGC (%) − 1.9 ± 3.6 − 3.2 ± 5.5 − 0.3 [− 2.6, 2.0] 0.807
 Myocardial TGC (%) 0.1 ± 0.5 − 0.1 ± 0.6 0.2 [− 0.1, 0.5] 0.157
  1. Results are presented as n (%) or mean ± SD. n = 44. Missing data in the liraglutide group: n = 3 for epicardial adipose tissue volume and paracardial adipose tissue volume. Missing data in placebo group: n = 1 for lean body mass (kg and %), n = 3 for epicardial adipose tissue volume, n = 2 for paracardial adipose tissue volume, and n = 1 for myocardial triglyceride content
  2. AT adipose tissue, TGC triglyceride content