Characteristic | Liraglutide (n = 22) | Placebo (n = 25) |
---|---|---|
Demographics | ||
 Age (year) | 55 ± 11 | 55 ± 9 |
Sex (no. (%)) | ||
 Male | 8 (36%) | 11 (44%) |
 Female | 14 (64%) | 14 (56%) |
Diabetes duration (years) | 19 ± 10 | 17 ± 10 |
Concomitant drug use | ||
 Metformin (no. (%)) | 22 (100%) | 23 (92%) |
 Metformin dose (g/day) | 1.8 ± 0.7 | 1.7 ± 0.6 |
 Sulfonylurea (no. (%)) | 3 (14%) | 5 (20%) |
 Insulin (no. (%)) | 17 (77%) | 19 (76%) |
 Insulin dose (units/day) | 77 ± 34 | 67 ± 30 |
 Lipid-lowering drugs (statin and/or other), no. (%) | 17 (77%) | 20 (80%) |
Clinical parameters | ||
 Body weight (kg) | 81.9 ± 11.0 | 77.8 ± 12.4 |
 BMI (kg/m2) | 30.4 ± 3.8 | 28.6 ± 4.0 |
 Waist circumference (cm) | 104 ± 8 | 98 ± 10 |
 Hip circumference (cm) | 104 ± 7 | 104 ± 9 |
 Waist-hip ratio | 1.00 ± 0.07 | 0.95 ± 0.09 |
 Lean body mass (kg) | 51.6 ± 10.6 | 48.9 ± 11.2 |
 Lean body mass (%) | 62.8 ± 8.4 | 63.1 ± 9.8 |
Metabolic factors | ||
 HbA1c (mmol/mol) | 65 ± 10 | 70 ± 12 |
 HbA1c (%) | 8.1 ± 0.9 | 8.6 ± 1.1 |
 Total cholesterol (mmol/L) | 3.95 ± 0.65 | 4.46 ± 1.10 |
 HDL-cholesterol (mmol/L) | 1.24 ± 0.33 | 1.21 ± 0.30 |
 LDL-cholesterol (mmol/L) | 2.00 ± 0.65 | 2.21 ± 0.97 |
 Triglycerides (mmol/L) | 1.55 ± 0.86 | 2.08 ± 1.80 |
Adipose tissue compartments | ||
 Subcutaneous AT (cm2) | 315 ± 97 | 326 ± 141 |
 Visceral AT (cm2) | 187 ± 57 | 149 ± 49 |
 Epicardial AT (cm2) | 10 ± 3 | 9 ± 3 |
 Paracardial AT (cm2) | 12 ± 4 | 9 ± 4 |
 Hepatic TGC (%) | 6.9 ± 6.3 | 11.8 ± 10.9 |
 Myocardial TGC (%) | 0.9 ± 0.4 | 1.0 ± 0.6 |