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Table 1 Baseline cardiac function of ex vivo perfused hearts with or without phlorizin-perfusion

From: Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity

  NFD
(n = 6)
NFD-phlorizin
(n = 6)
HFD
(n = 8)
HFD-phlorizin
(n = 8)
LVSP, mmHg 98.9 ± 5.1 112 ± 8.5 119 ± 4.9* 133 ± 11*
LVEDP, mmHg 9.2 ± 0.4 10 ± 0.8 9.6 ± 0.2 9.4 ± 0.5
LVDP, mmHg 89.8 ± 5.1 102 ± 8.9 109 ± 5.0* 123 ± 11*
+dp/dt, mmHg/s 2742 ± 247 3277 ± 308 3478 ± 162 4098 ± 463
−dp/dt, mmHg/s − 2308 ± 200 − 2450 ± 277 − 2814 ± 177 − 3380 ± 518
HR, bpm 272 ± 44 306 ± 35 266 ± 27 284 ± 22
RPP, mmHg bpm 25,429 ± 5192 31,251 ± 4897 28,650 ± 2714 35,970 ± 5245
Coronary flow, mL/min 3.30 ± 0.47 2.93 ± 0.36 3.19 ± 0.32 3.58 ± 0.38
  1. NFD normal fat diet, HFD high fat diet, LVSP left ventricular systolic pressure, LVEDP left ventricular end-diastolic pressure, LVDP left ventricular developed pressure, HR heart rate, RPP rate pressure product
  2. *P < 0.05 versus NFD group