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Table 1 Baseline cardiac function of ex vivo perfused hearts with or without phlorizin-perfusion

From: Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity

 

NFD

(n = 6)

NFD-phlorizin

(n = 6)

HFD

(n = 8)

HFD-phlorizin

(n = 8)

LVSP, mmHg

98.9 ± 5.1

112 ± 8.5

119 ± 4.9*

133 ± 11*

LVEDP, mmHg

9.2 ± 0.4

10 ± 0.8

9.6 ± 0.2

9.4 ± 0.5

LVDP, mmHg

89.8 ± 5.1

102 ± 8.9

109 ± 5.0*

123 ± 11*

+dp/dt, mmHg/s

2742 ± 247

3277 ± 308

3478 ± 162

4098 ± 463

−dp/dt, mmHg/s

− 2308 ± 200

− 2450 ± 277

− 2814 ± 177

− 3380 ± 518

HR, bpm

272 ± 44

306 ± 35

266 ± 27

284 ± 22

RPP, mmHg bpm

25,429 ± 5192

31,251 ± 4897

28,650 ± 2714

35,970 ± 5245

Coronary flow, mL/min

3.30 ± 0.47

2.93 ± 0.36

3.19 ± 0.32

3.58 ± 0.38

  1. NFD normal fat diet, HFD high fat diet, LVSP left ventricular systolic pressure, LVEDP left ventricular end-diastolic pressure, LVDP left ventricular developed pressure, HR heart rate, RPP rate pressure product
  2. *P < 0.05 versus NFD group