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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity

Fig. 3

Myocardial injury after ischemia–reperfusion with or without phlorizin-perfusion. a CPK profiles in the effluent collected during the reperfusion period. b The area under the curve (AUC) was calculated from the CPK profile shown in a (NFD; n = 11, NFD with phlorizin-perfusion; n = 7, HFD; n = 10, HFD with phlorizin-perfusion; n = 4). *P < 0.05 and **P < 0.01 versus the NFD group at each time point; P < 0.05 and P < 0.01 versus the HFD group at each time point. c Micrograph showing representative TTC staining of cardiac sections obtained from NFD, NFD with phlorizin-perfusion, HFD, and HFD with phlorizin-perfusion groups after ischemia–reperfusion. Bars = 3 mm. d Effects on the quantitated cumulative infarct area size in NFD (n = 9), NFD phlorizin-perfused (n = 6), HFD (n = 5), and HFD phlorizin-perfused (n = 4) hearts. **P < 0.01 versus the NFD group; P < 0.05 versus the HFD group. %MI myocardial infarct area/ventricular area

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