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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity

Fig. 2

Cardiac functional recovery after ischemia–reperfusion injury with or without phlorizin-perfusion. a Experimental protocols indicating the duration and time course of ischemia/reperfusion are shown. The CPK activity released into the perfusate was measured at the point in the protocol indicated by the solid arrows. b Representative tracing of LVDP during ischemia–reperfusion with or without phlorizin-perfusion. LVDP profiles (c) and LVDP recovery (percent of baseline) (d) measured at the indicated time points during ischemia–reperfusion in NFD (open black square; n = 6), NFD phlorizin-perfused (filled black square; n = 6), HFD (open pink square; n = 8), and HFD phlorizin-perfused (filled pink square; n = 6) hearts are shown. *P < 0.05 and **P < 0.01 versus the NFD group at each time point; †P < 0.05 and ‡P < 0.01 versus the HFD group at each time point. SGLT2i SGLT2-inhibitors, min minutes, LVDP left ventricular developed pressure, I ischemia, R reperfusion

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Cardiovascular Diabetology

ISSN: 1475-2840