Fig. 3
From: Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice
Ipra suppresses monocytes and VSMCs migration. a Representative pictures and quantitative data of migrated monocytes (WEHI274.1 cells) under CM of Epi with or without anti-MCP-1 blocking antibody (anti-MCP-1 Ab, 2 μg/ml). b Expression levels of proliferation- and migration-related genes in abdominal PVAT. c Leptin concentration in CM of abdominal PVAT. d Representative pictures and quantitative data of PDGF-BB-induced primary cultured VSMCs migration under CM of abdominal PVAT with or without LY294002 (10 μM). VSMCs, vascular smooth muscle cells. ns not significant. *p < 0.05, **p < 0.01 vs SD. #p < 0.05, ##p < 0.01 vs WD. n = 6–8