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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice

Fig. 2

Ipra attenuates inflammation, fibrosis, and cell death in abdominal PVAT of WD-fed mice. a Expression levels of inflammation- and fibrosis-related genes in abdominal PVAT of SD- or WD-fed WT mice after 10 weeks of Ipra treatment. b Representative pictures of F4/80 immunostaining and quantitative data, and the number of crown-like structure (CLS) in abdominal PVAT. c Representative pictures of Sirius red staining and quantitative data in abdominal PVAT. d Representative pictures of TUNEL staining and quantitative data in abdominal PVAT. Quantitative data of HMGB1 protein in e abdominal PVAT. Epi epididymal adipose tisse. Original magnification, ×200 (F4/80), ×40 (Sirius red). *p < 0.05, **p < 0.01 vs SD. #p < 0.05, ##p < 0.01 vs WD. n = 6–8

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