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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice

Fig. 1

Ipra increases adipocyte size with enhanced insulin signaling in abdominal PVAT of WD-fed mice. The changes in a body weight and b blood glucose, and c area under curve (AUC) of blood glucose in SD- or WD-fed WT mice during Ipra treatment for 10 weeks. d Plasma insulin concentration and e HOMA-IR after 10 weeks of Ipra treatment. f Hematoxylin and eosin (HE) staining, and g quantification and h histogram of adipocyte size in abdominal PVAT. Quantitative data of i perilipin-1 and j phosphorylated Akt (p-Akt) in abdominal PVAT. WT wild-type, SD standard diet, WD Western-type diet, Ipra ipragliflozin, PVAT perivascular adipose tissue. Original magnification, ×200. *p < 0.05, **p < 0.01 vs SD. #p < 0.05, ##p < 0.01 vs WD. n = 6–8

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