Table 1 Inclusion and exclusion criteria

Age older than 40 affected by type 2 diabetes mellitus

Inability or refusal to sign informed consent for inclusion of the study

Renal failure with eGFR < 30 ml/min

State of pregnancy established or presumed

History of solid or hematological neoplasia or active neoplasia

Transplant holder of a solid organ or subjected to bone marrow transplantation

Gastro-intestinal resection

Unfavorable prognosis at the judgment of the clinician, or life expectancy of less than 12 months

Autoimmune or chronic inflammatory pathology

Confirmed liver cirrhosis with Child–Pugh C functional impairment

Confirmed or suspected monogenic hereditary dyslipidemia

Confirmed acquired platelets or congenital platelets disease

Confirmed congenital hemorrhagic diathesis or acquired coagulopathies; Congenital or acquired thrombophilia