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Table 3 Changes of the blood pressure, heart rate, PVW, ABI, echocardiographic data

From: Canagliflozin for Japanese patients with chronic heart failure and type II diabetes

 

Pre

6 months

12 months

S-BP (mmHg)

136.2 ± 2.7

127.5 ± 3.0*

130.1 ± 3.2

D-BP (mmHg)

76.9 ± 1.2

72.7 ± 1.7*

75.2 ± 1.9

Heart rate (/min)

66.9 ± 1.6

65.5 ± 2.2

68.2 ± 1.3

Right PWV (cm/s)

1821.7 ± 70.6

1713.9 ± 64.0*

1784.1 ± 67.0

left PWV (cm/s)

1883.1 ± 82.5

1715.2 ± 69.4*

1814.4 ± 76.7

Right ABI

1.15 ± 0.02

1.14 ± 0.02

1.12 ± 0.03

Left ABI

1.15 ± 0.02

1.14 ± 0.02

1.12 ± 0.02

Echocardiography

 LVDd (mm)

47.1 ± 1.1

45.7 ± 0.9

46.3 ± 1.0

 LVDs (mm)

31.6 ± 0.8

30.4 ± 0.7*

29.9 ± 0.8*

 Ejection fraction (%)

60.9 ± 1.6

61.9 ± 1.5

64.6 ± 1.3*$

 % fractional shortening (%)

33.0 ± 0.9

33.4 ± 1.0

35.4 ± 0.9*$

LVMI (g/m2)

166.5 ± 6.4

147.7 ± 5.8*

140.6 ± 5.4*$

  1. S-BP systolic blood pressure, D-BP diastolic blood pressure, PWV pulse power velocity, ABI ankle–brachial pressure index, LVDd left ventricular end-diastolic diameter, LVDs left ventricular end-systolic diameter, LVMI left ventricular mass index
  2. p < 0.05, pre vs. each level, $ p < 0.05, 6 months vs. 12 months