Variables | Baseline | After | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | P-value | 1 | 2 | 3 | 4 | P-value | |
Left cardiac structure | ||||||||||
 LA, mm | 32.20 ± 6.00 | 31.25 ± 5.09 | 31.87 ± 4.89 | 30.54 ± 4.88 | 0.086 | 33.26 ± 5.61 | 33.54 ± 5.00 | 32.82 ± 4.85 | 34.49 ± 5.01 | 0.095 |
 LVDd, mm | 47.40 ± 4.63 | 44.75 ± 4.11 | 44.54 ± 4.32 | 44.65 ± 3.85 | < 0.001 | 48.51 ± 4.52 | 48.12 ± 4.25 | 47.63 ± 4.70 | 49.44 ± 3.87 | 0.015 |
 IVS, mm | 12.87 ± 2.06 | 12.60 ± 2.04 | 12.63 ± 1.85 | 12.44 ± 1.75 | 0.418 | 11.90 ± 2.19 | 12.53 ± 1.81 | 12.44 ± 2.00 | 13.09 ± 1.93 | < 0.001 |
 LVPW, mm | 9.34 ± 1.60 | 9.51 ± 1.72 | 9.40 ± 1.69 | 9.60 ± 1.63 | 0.653 | 9.67 ± 1.47 | 9.78 ± 1.62 | 9.93 ± 1.76 | 10.93 ± 1.66 | < 0.001 |
 LVMI, g/m2 | 110.46 ± 30.64 | 99.01 ± 25.14 | 98.61 ± 25.26 | 99.11 ± 26.58 | 0.001 | 110.55 ± 32.16 | 112.73 ± 29.13 | 113.23 ± 34.44 | 130.85 ± 31.34 | < 0.001 |
Left ventricular systolic function | ||||||||||
 LVEF, % | 57.06 ± 5.32 | 58.82 ± 5.57 | 58.91 ± 5.93 | 57.22 ± 5.19 | 0.011 | 55.75 ± 7.41 | 56.20 ± 6.00 | 55.51 ± 6.35 | 51.90 ± 7.37 | < 0.001 |
Left ventricular diastolic function | ||||||||||
 E velocity, cm/s | 0.74 ± 0.19 | 0.77 ± 0.22 | 0.79 ± 0.25 | 0.78 ± 0.23 | 0.296 | 0.77 ± 0.18 | 0.80 ± 0.21 | 0.85 ± 0.26 | 0.82 ± 0.23 | 0.029 |
 A velocity, cm/s | 0.80 ± 0.19 | 0.83 ± 0.20 | 0.91 ± 0.33 | 0.82 ± 0.24 | 0.007 | 0.88 ± 0.21 | 0.93 ± 0.27 | 0.97 ± 0.32 | 0.92 ± 0.27 | 0.117 |
 E/A ratio | 0.98 ± 0.36 | 0.97 ± 0.33 | 0.95 ± 0.36 | 1.00 ± 0.33 | 0.677 | 0.91 ± 0.31 | 0.89 ± 0.26 | 0.93 ± 0.34 | 0.94 ± 0.32 | 0.721 |
 Tissue Doppler e′, cm/s | 0.10 ± 0.03 | 0.11 ± 0.03 | 0.11 ± 0.03 | 0.11 ± 0.03 | 0.220 | 0.09 ± 0.03 | 0.09 ± 0.02 | 0.09 ± 0.02 | 0.09 ± 0.03 | 0.936 |
 E/e′ ratio | 7.67 ± 3.10 | 7.41 ± 2.91 | 7.69 ± 3.36 | 7.89 ± 3.58 | 0.740 | 9.04 ± 3.87 | 9.28 ± 3.65 | 9.78 ± 4.21 | 9.25 ± 3.61 | 0.517 |