Table 2 Characteristics of healthy controls, hypertensive patients with and without hydrochlorothiazide treatment and patients with type 2 diabetes with and without SGLT2 inhibitor treatment

n

16

14

16

13

5

na

Age (years)

50 (35; 61)

56 (48; 63)

52 (43; 58)

64 (56; 71)

56 (54; 73)

0.0098

Sex (male)

4 (25%)

3 (21%)

5 (31%)

4 (31%)

5 (100%)

0.0472

BMI (kg/m²)

29.0 (24.8; 30.4)

30.1 (25.6; 33.4)

28.8 (25.0; 32.5)

32.7 (27.8; 37.6)

32.2 (30.5; 35.6)

0.1195

Body weight (kg)

74.9 (71.1; 84.5)

78.6 (71.0; 100.8)

83.2 (67.4; 95.4)

87.0 (72.6; 113.5)

89.7 (65.8; 98.9)

0.1409

Creatinine (mg/dL)

0.7 (0.6; 0.9)

0.8 (0.7; 0.8)

0.8 (0.6; 1.0)

0.7 (0.5; 0.9)^a

0.6 (0.6;0.9)

0.5019

Proteinuria (mg/g creatinine)

12.6 (6.3; 16.2)

19.3 (13.5; 24.0)

11.4 (10.2; 18.3)

136 (69;197)^a

137 (120; 619)

< 0.0001

Renin (ng Ang L/mL/h)

1.3 (0.4; 3.1)

1.8 (0.3; 5.6)

2.8 (0.7; 6.7)

2.5 (0.9; 7.5)

4.5 (2.3; 21)

0.0986

Aldosterone (pg/mL)

161 (123; 194)

106 (75; 163)

102 (96; 146)

79 (64; 105)

112 (68; 147)

0.0254

Medication with RAAS inhibitor

0

11 (79%)

14 (88%)

12 (92%)

5 (100%)

na