|
Predictors
|
U β (95% CI)
|
p-value
|
M β (95% CI)*
|
p-value
|
|---|
|
Peak thrombin
|
|
cfDNA
|
40.83 (22.65 to 59.02)
|
< 0.001
|
17.10 (7.24 to 26.95)
|
< 0.001
|
|
Metformin
|
12.68 (− 34.07 to 8.71)
|
0.24
|
− 14.5 (− 25.20 to − 3.85)
|
0.008
|
|
BMI
|
1.23 (− 2.13 to 4.59)
|
0.47
|
1.86 (0.24 to 3.48)
|
0.025
|
|
Ks
|
|
H3Cit
|
− 0.10 (− 0.14 to − 0.06)
|
< 0.001
|
− 0.08 (− 0.11 to − 0.04)
|
< 0.001
|
|
CLT
|
|
H3Cit
|
3.06 (2.28 to 3.85)
|
< 0.001
|
2.70 (1.93 to 3.46)
|
< 0.001
|
|
PAI-1
|
1.00 (0.52 to 1.46)
|
< 0.001
|
0.58 (0.17 to 0.99)
|
0.006
|
|
CVD
|
7.09 (3.73 to 10.46)
|
< 0.001
|
3.91 (1.05 to 6.76)
|
0.008
|
|
Time since T2DM diagnosis ≥ 10 years
|
4.26 (0.64 to 7.88)
|
0.022
|
3.15 (0.30 to 6.01)
|
0.031
|
|
CLT
|
|
cfDNA
|
9.38 (5.93 to 12.83)
|
< 0.001
|
8.26 (5.04 to 11.48)
|
< 0.001
|
|
PAI-1
|
1.00 (0.52 to 1.46)
|
< 0.001
|
0.80 (0.37 to 1.23)
|
< 0.001
|
|
CVD
|
7.09 (3.73 to 10.46)
|
< 0.001
|
5.46 (2.49 to 8.43)
|
< 0.001
|
- BMI, body-mass index; PAI-1, plasminogen-activator inhibitor type 1; T2DM, type 2 diabetes mellitus; CVD, cardiovascular disease
- Data are presented as regression coefficients derived from the univariate and multivariate regression models. Due to the strong correlation between citrullinated histone 3 (H3Cit) and cell-free deoxyribonucleic acid (cfDNA), two separate multivariate models for CLT were provided
- * Adjusted for age, gender and fibrinogen
