Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis

Table 3 Univariate and multivariate models for predictors of peak thrombin, clot permeability (K_s) and clot lysis time (CLT)

Predictors	U β (95% CI)	p-value	M β (95% CI)*	p-value
Peak thrombin
cfDNA	40.83 (22.65 to 59.02)	< 0.001	17.10 (7.24 to 26.95)	< 0.001
Metformin	12.68 (− 34.07 to 8.71)	0.24	− 14.5 (− 25.20 to − 3.85)	0.008
BMI	1.23 (− 2.13 to 4.59)	0.47	1.86 (0.24 to 3.48)	0.025
K_s
H3Cit	− 0.10 (− 0.14 to − 0.06)	< 0.001	− 0.08 (− 0.11 to − 0.04)	< 0.001
CLT
H3Cit	3.06 (2.28 to 3.85)	< 0.001	2.70 (1.93 to 3.46)	< 0.001
PAI-1	1.00 (0.52 to 1.46)	< 0.001	0.58 (0.17 to 0.99)	0.006
CVD	7.09 (3.73 to 10.46)	< 0.001	3.91 (1.05 to 6.76)	0.008
Time since T2DM diagnosis ≥ 10 years	4.26 (0.64 to 7.88)	0.022	3.15 (0.30 to 6.01)	0.031
CLT
cfDNA	9.38 (5.93 to 12.83)	< 0.001	8.26 (5.04 to 11.48)	< 0.001
PAI-1	1.00 (0.52 to 1.46)	< 0.001	0.80 (0.37 to 1.23)	< 0.001
CVD	7.09 (3.73 to 10.46)	< 0.001	5.46 (2.49 to 8.43)	< 0.001

BMI, body-mass index; PAI-1, plasminogen-activator inhibitor type 1; T2DM, type 2 diabetes mellitus; CVD, cardiovascular disease
Data are presented as regression coefficients derived from the univariate and multivariate regression models. Due to the strong correlation between citrullinated histone 3 (H3Cit) and cell-free deoxyribonucleic acid (cfDNA), two separate multivariate models for CLT were provided
* Adjusted for age, gender and fibrinogen

ISSN: 1475-2840