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Table 3 Univariate and multivariate models for predictors of peak thrombin, clot permeability (Ks) and clot lysis time (CLT)

From: Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis

Predictors U β (95% CI) p-value M β (95% CI)* p-value
Peak thrombin
 cfDNA 40.83 (22.65 to 59.02) < 0.001 17.10 (7.24 to 26.95) < 0.001
 Metformin 12.68 (− 34.07 to 8.71) 0.24 − 14.5 (− 25.20 to − 3.85) 0.008
 BMI 1.23 (− 2.13 to 4.59) 0.47 1.86 (0.24 to 3.48) 0.025
Ks
 H3Cit − 0.10 (− 0.14 to − 0.06) < 0.001 − 0.08 (− 0.11 to − 0.04) < 0.001
CLT
 H3Cit 3.06 (2.28 to 3.85) < 0.001 2.70 (1.93 to 3.46) < 0.001
 PAI-1 1.00 (0.52 to 1.46) < 0.001 0.58 (0.17 to 0.99) 0.006
 CVD 7.09 (3.73 to 10.46) < 0.001 3.91 (1.05 to 6.76) 0.008
 Time since T2DM diagnosis ≥ 10 years 4.26 (0.64 to 7.88) 0.022 3.15 (0.30 to 6.01) 0.031
CLT
 cfDNA 9.38 (5.93 to 12.83) < 0.001 8.26 (5.04 to 11.48) < 0.001
 PAI-1 1.00 (0.52 to 1.46) < 0.001 0.80 (0.37 to 1.23) < 0.001
 CVD 7.09 (3.73 to 10.46) < 0.001 5.46 (2.49 to 8.43) < 0.001
  1. BMI, body-mass index; PAI-1, plasminogen-activator inhibitor type 1; T2DM, type 2 diabetes mellitus; CVD, cardiovascular disease
  2. Data are presented as regression coefficients derived from the univariate and multivariate regression models. Due to the strong correlation between citrullinated histone 3 (H3Cit) and cell-free deoxyribonucleic acid (cfDNA), two separate multivariate models for CLT were provided
  3. * Adjusted for age, gender and fibrinogen