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Table 2 Comparison of coagulation and fibrinolysis proteins and clot phenotype parameters in patients in relation to citrullinated histone 3 (H3Cit) and cell-free deoxyribonucleic acid (cfDNA)

From: Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis

Variable Patients with H3Cit ≥ 7.36 ng/mL (n = 28) Patients without H3Cit < 7.36 ng/mL (n = 84*) p-value Patients with cfDNA ≥ 2.84 µg/mL (n = 28) Patients with cfDNA < 2.84 µg/mL (n = 84*) p-value
Coagulation and fibrinolysis components
 Fibrinogen, g/L 3.54 (3.20–4.02) 3.45 (3.09–3.85) 0.17 3.56 (3.17–3.87) 3.44 (3.10–3.9) 0.44
 α2-antiplasmin,  % 106.0 (102.0–112.0) 103.0 (96.0–110.0) 0.07 104.5 (96.0–111.5) 104.0 (98.0–110.0) 0.88
 Plasminogen,  % 110.0 (101.5–118.5) 108.0 (99.0–120.0) 0.55 109.5 (97.5–127.5) 109.0 (100.0–118.8) 0.75
 PAI-1, ng/mL 36.4 (32.0–45.4) 35.0 (30.6–40.9) 0.19 37.6 (33.0–44.8) 35.0 (30.8–40.9) 0.13
 TAFI,  % 104.0 (96.5–119.3) 101.5 (90.0–114.0) 0.06 109.0 (93.5–120.5) 102.0 (90.0–113.8) 0.07
Endothelial injury marker
 Thrombomodulin, ng/mL 3.02 (2.45–3.80) 2.80 (2.35–3.11) 0.056 2.95 (2.47–3.73) 2.74 (2.33–3.19) 0.13
Interleukins
 Interleukin 6, pg/mL 7.19 (5.17–8.78) 3.02 (2.19–4.63) < 0.001 6.14 (3.25–8.46) 3.52 (2.22–5.19) < 0.001
 Interleukin 8, pg/mL 8.26 (6.08–9.37) 4.28 (3.29–6.27) < 0.001 7.72 (4.83–9.22) 4.73 (3.61–6.79) < 0.001
Thrombin generation
 Lag phase, s 1053 (763–1343) 1004 (777–1350) 0.82 897 (762–1182) 1,050 (789–1383) 0.13
 Peak thrombin, nmol 115.7 (90.0–166.6) 116.8 (87.7–153.5) 0.45 142.3 (100.0–188.0) 112.5 (86.6–147.2) 0.012
 Time-to-peak, s 1369 (1067–2035) 1395 (1128–1889) 0.94 1184 (1019–1559) 1417 (1149–1892) 0.08
 ETP, nM × s 104,732 (92,039–122,405) 103,810 (83,751–126,823) 0.93 111,864 (94,181–134,420) 103,810 (81,390–121,805) 0.26
Platelet markers
 P-selectin, ng/mL 62.9 (46.1–88.1) 72.4 (52.4–91.7) 0.45 70.7 (47.0–88.4) 68.1 (51.43–91.7) 0.63
 Platelet factor 4, ng/mL 80.5 (64.8–89.6) 82.0 (70.7–90.8) 0.40 80.5 (72.2–88.7) 82.6 (68.9–91.3) 0.45
Clot permeability
 Ks, × 10−9 cm2 5.90 (5.15–6.40) 6.65 (6.20–7.10) < 0.001 6.20 (5.58–6.88) 6.50 (6.00–7.00) 0.022
Clot lysis time, min 114.0 (99.3–126.8) 87.0 (78.3–100.0) < 0.001 103.5 (90.0–125.0) 89.0 (79.0–103.0) 0.001
  1. Values are given as mean ± SD or median (interquartile range)
  2. PAI-1, plasminogen activator inhibitor 1; TAFI, thrombin activatable fibrinolysis inhibitor; ETP, endogenous thrombin potential; Ks, Darcy’s constant (permeability coefficient)
  3. * Data on H3Cit and cfDNA levels were missing for one patient