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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats

Fig. 6

Empagliflozin attenuates hypertension-induced collagen deposition in cardiac fibrosis of left atrial and left ventricular. Collagen fiber deposition and arrangement was demonstrated by second-harmonic generation (SHG) microscopy for left atrial (a) and left ventricular (b) tissue of normo-tensive rats (WKY), spontaneous hypertensive rats (SHR), and empagliflozin-treated SHR (EMPA). All scans are transmural and show the whole myocardial wall (from left to right: endocardium or luminal surface to epicardium or pericardium). Collagen deposition is demonstrated with high SHG intensity

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