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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats

Fig. 5

Attenuated fibrosis in empagliflozin-treated atria and ventricles. Gross hearts (a), histological sections (b), Masson trichrome staining of atrial tissue (c) and ventricular tissue (shown in cross, longitudinal sections, and peri-vascular sections) (d) of high-fat-fed wild type (WKY), spontaneous hypertensive rats (SHR), and empagliflozin-treated SHR (EMPA). e The numerical data of the heart weight was shown. The quantified fibrosis area shows significant increase in SHR compared to WKY and significant attenuation by EMPA, in both atrial (f *P = 0.0045; #P < 0.0001) and ventricular tissue (g *P < 0.0001; #P = 0.0084; $P = 0.0002)

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