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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

Fig. 6

Sacubitril/valsartan reduces a glomerular and b tubulointerstitial nitroso-oxidative stress in ZO rats. Representative images of 3-nitrotyrosine immunostaining as a marker for nitroso-oxidative stress with accompanying bar graphs showing quantitation of measures of intensity. Data are represented by mean ± SE. n = 5–7 rats per group. c–e Bar graphs show NOX2, NOX4 and AT1R mRNA expression normalized to 18S mRNA and expressed as a fold change from baseline in ZLC group (n = 4 per group). Symbols: *p < 0.05 versus ZLC; †p < 0.05 versus ZOC

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Cardiovascular Diabetology

ISSN: 1475-2840