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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

Fig. 4

Sacubitril/valsartan improves tubular ultrastructure. Representative TEM images showing ultrastructural remodeling in proximal tubule cells (PTC). a Normal basilar S-1 PTC in ZLC showing electron dense mitochondrial and canalicular morphology. Image also shows adjacent glomerulus with normal podocyte foot processes (POD fp). b Depicts the loss of basilar mitochondria elongation with fragmentation, as well as loss of canalicular morphology in ZOC. c Depicts an improvement in S-1 PTC morphology in ZOSV characterized by elongated mitochondria, but without apparent improvement in canaliculi. d Also demonstrates abnormal S-1 PTC morphology in ZOV, however mitochondrial fragmentation is less apparent than in ZOC and some canaliculi appear normal. e Depicts a marked increase in mitochondrial fragmentation and abnormal chromatin condensation in the S-1 PTC nucleus in ZOH. These remodeling changes indicate marked cellular degeneration in the PTC. All images are ×2000 magnification; scale bar = 1 μm; G, glomerulus; Mt, mitochondria; C, canaliculi

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