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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

Fig. 3

Sacubitril/valsartan improves ultrastructure of the glomerular filtration barrier. a Representative micrographs show normal ultrastructure of the glomerular podocyte and adjacent slit pores in ZLC kidneys. b ZOC exhibited profound loss of endothelial fenestrae along with podocyte effacement and loss of slit pore diaphragm which were partially restored by sac/val treatment. Podocyte foot processes were markedly effaced and flattened in b ZOC, d ZOV and e ZOH, however they appeared more normal in c ZOSV. All images are ×2000 magnification; scale bar = 1 μm. fg Suppression of nephrin and podocin gene expression is rescued in ZOSV, but not ZOV or ZOH. Bar graphs show nephrin and podocin mRNA expression normalized to 18S mRNA and expressed as a fold change from baseline in ZLC group (n = 4 per group). *p < 0.05 versus ZLC; p < 0.05 versus ZOC; Δp < 0.05 versus ZOSV

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