How does empagliflozin improve arterial stiffness in patients with type 2 diabetes mellitus? Sub analysis of a clinical trial

Table 2 Results of multivariate regression analysis

Dependent variable: Δ central systolic blood pressure						Dependent variable: Δ central pulse pressure
Model 1	Beta	p-value	Model 2	Beta	p-value	Model 1	Beta	p-value	Model 2	Beta	p-value
Sex	0.134	0.379	Sex	0.195	0.191	Sex	0.155	0.255	Sex	0.211	0.110
Age	− 0.159	0.286	Age	− 0.186	0.205	Age	− 0.259	0.054	Age	− 0.282	0.032
Δ HbA1c	− 0.022	0.892	Δ Fasting plasma glucose	− 0.043	0.788	Δ HbA1c	0.012	0.933	Δ Fasting plasma glucose	− 0.169	0.238
Δ Copeptin	0.057	0.701	Δ Copeptin	0.054	0.710	Δ Copeptin	0.031	0.813	Δ Copeptin	0.037	0.769
Δ Hematocrit	− 0.092	0.565	Δ Hematocrit	− 0.096	0.556	Δ Hematocrit	− 0.145	0.309	Δ Hematocrit	− 0.189	0.192
Δ Heart rate	0.001	0.997	Δ Heart rate	0.043	0.787	Δ Heart rate	− 0.123	0.392	Δ Heart rate	− 0.056	0.686
Δ LDL-cholesterol	0.095	0.615	Δ LDL-cholesterol	0.074	0.631	Δ LDL-cholesterol	− 0.126	0.365	Δ LDL-cholesterol	− 0.146	0.287
Δ Uric acid	− 0.083	0.642	Δ Uric acid	− 0.027	0.878	Δ Uric acid	− 0.124	0.438	Δ Uric acid	− 0.112	0.478
Δ Systolic BP	0.412	0.018	Δ Systolic BP	0.355	0.024	Δ Systolic BP	0.364	0.019	Δ Systolic BP	0.332	0.017
Δ hsCRP	0.171	0.278	Δ hsCRP	0.192	0.231	Δ hsCRP	0.305	0.033	Δ hsCRP	0.347	0.017

Model 1: Multivariate regression analysis was performed including the parameters sex, age and change of the following parameters under treatment with empagliflozin: HbA1c (model 1), copeptin concentration, hematocrit, 24-h ambulatory heart rate, LDL-cholesterol, uric acid, systolic 24-h ambulatory blood pressure and hsCRP. Model 2 included besides the other previously mentioned parameters fasting plasma glucose instead of HbA1c. LDL-cholesterol low density lipid cholesterol, hsCRP high sensitive C-reactive protein, heart rate 24-h ambulatory heart rate, systolic BP systolic 24-h ambulatory blood pressure, “Δ” refers to the changes due to empagliflozin treatment corrected for the placebo changes
Italic values indicate significance of p-value (p < 0.05)

ISSN: 1475-2840