Type 2 diabetes mellitus increases long-term mortality risk after isolated surgical aortic valve replacement

Table 3 Hazard ratios for mortality at 1-, 3-, 5-, and 10-years, adjusted for age

	1-year			3-year			5-year			10-year
	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Diabetes	1.33	0.82–2.15	0.250	1.37	0.92–2.04	0.117	1.47	1.07–2.01	0.018	1.44	1.12–1.84	0.004
Gender (male)	1.51	0.93–2.45	0.097	1.55	1.04–2.32	0.031	1.31	0.96–1.79	0.093	1.12	0.88–1.43	0.348
Obesity	0.72	0.39–1.32	0.288	0.92	0.58–1.45	0.713	0.87	0.59–1.26	0.454	0.95	0.72–1.26	0.737
Hypertension	0.67	0.4–1.12	0.129	0.67	0.44–1.03	0.068	0.83	0.57–1.19	0.307	0.91	0.68–1.21	0.521
PVD	2.45	1.21–4.95	0.013	2.90	1.67–5.02	0.000	2.58	1.61–4.14	0.000	2.08	1.4–3.07	0.000
Previous MI	1.61	0.82–3.17	0.168	1.53	0.87–2.7	0.143	1.32	0.82–2.11	0.253	1.19	0.82–1.71	0.356
Hyperlipidemia	0.49	0.3–0.79	0.004	0.63	0.42–0.93	0.022	0.69	0.5–0.95	0.024	0.79	0.62–1.01	0.059
Smoking	0.59	0.29–1.18	0.137	0.95	0.58–1.56	0.850	0.9	0.6–1.34	0.602	0.96	0.71–1.31	0.812
COPD	2.05	1.07–3.9	0.030	2.18	1.3–3.68	0.004	2.46	1.62–3.72	0.000	2.42	1.72–3.41	0.000
NYHA FC III–IV	1.23	0.76–2	0.393	1.24	0.83–1.84	0.289	1.32	0.96–1.81	0.086	1.28	1.01–1.64	0.045
Ejection fraction	0.96	0.95–0.98	0.000	0.97	0.95–0.98	0.000	0.97	0.96–0.99	0.000	0.98	0.97–0.99	0.000

PVD peripheral vascular disease, MI myocardial dysfunction, COPD chronic obstruction pulmonary disease, NYHA FC New York Heart Association functional class

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