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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype

Fig. 6

Histological evaluation of left ventricular at 3 days and 8 weeks after implantation. a, b Representative whole microscopic images of Sirius red staining in each group. Quantification of percent fibrosis and fibrotic area. Fibrosis at areas remote to the infarct zone was significantly suppressed in the A, AP, and Si groups compared to that in the C group 8 weeks after transplantation. Scale bar = 50 μm. Evaluation of hypertrophy of cardiomyocytes. c, d Representative periodic acid-Schiff staining of tissue infarct border site. Quantification of cardiomyocyte diameter. Cardiomyocyte diameters in the borders of the infarct sites were significantly smaller in the A and AP groups than in the C group. Especially at 8 weeks diameters in AP group was significantly smaller than the other three groups. e, f Capillary density in the area bordering the infarct zone and areas remote to infarction. Capillaries stained by immunostaining with an anti-von Willebrand factor antibody were significantly denser in the A and AP groups than C and Si groups at 3 days. At 8 weeks the density in AP group was significantly larger than the other three groups. n = 8–10 per group; *P < 0.05 versus C group, **P < 0.05 versus A group, †P < 0.05 versus Si group. Scale bar = 50 μm

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