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Table 3 Determination of cut-off optimum truncation point into the discrimination of glycemic status

From: Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

 

Cut-off

SE (%)

SP (%)

PPV (%)

NPV (%)

LR+

LR−

p value

AUC

NGT vs IGT

miR-21

≥ 0.0131

86

69

76

82

2.8

0.2

0.0004

0.812

SOD2

< 2388.6

56

97

93

72

16.24

0.5

0.0028

0.743

HNE

≥ 3.184

92

35

60

81

1.42

0.22

0.0736

0.629

ROS

≥ 0.19

76

95

92

84

15.17

0.25

< 0.0001

0.835

IGT vs T2D

miR-21

< 0.0466

93

35

47

88

1.42

0.21

0.0353

0.645

SOD2

< 2932.5

92

40

61

83

1.53

0.2

0.0783

0.613

HNE

≥ 10.12

70

82

73

80

3.92

0.36

0.0275

0.738

ROS

≥ 0.203

92

72

74

91

3.34

0.11

0.0005

0.872

  1. The italic values are statistical significance
  2. SE, sensitivity; SP, specificity; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; AUC, area under the curve
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Cardiovascular Diabetology

ISSN: 1475-2840