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Table 3 Determination of cut-off optimum truncation point into the discrimination of glycemic status

From: Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

  Cut-off SE (%) SP (%) PPV (%) NPV (%) LR+ LR− p value AUC
NGT vs IGT
miR-21 ≥ 0.0131 86 69 76 82 2.8 0.2 0.0004 0.812
SOD2 < 2388.6 56 97 93 72 16.24 0.5 0.0028 0.743
HNE ≥ 3.184 92 35 60 81 1.42 0.22 0.0736 0.629
ROS ≥ 0.19 76 95 92 84 15.17 0.25 <0.0001 0.835
IGT vs T2D
miR-21 < 0.0466 93 35 47 88 1.42 0.21 0.0353 0.645
SOD2 < 2932.5 92 40 61 83 1.53 0.2 0.0783 0.613
HNE ≥ 10.12 70 82 73 80 3.92 0.36 0.0275 0.738
ROS ≥ 0.203 92 72 74 91 3.34 0.11 0.0005 0.872
  1. The italic values are statistical significance
  2. SE, sensitivity; SP, specificity; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; AUC, area under the curve