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Table 1 Characteristic baseline of subjects

From: Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

 

NGT

IGT

T2

Overall

n

%male

n

%male

p (vs NG)

n

%male

p (vs NG)

p*

Sex

44

 

44

 

0.085

27

 

0.8

0.19

F

29

65.91

21

47.73

 

17

62.96

  

M

15

34.09

23

52.27

 

10

37.04

  
 

NGT

IGT

T2

Overall

n

Mean (± SD)

n

Mean (± SD)

p (vs NG)

n

Mean (± SD)

p (vs NG)

p*

Age (years)

44

59.3 (9.82)

44

61.52 (12.7)

0.2743

27

61.69 (7.59)

0.6886

0.283

BMI (kg/m2)

44

25.11 (3.32)

44

27.02 (3.61)

0.029

27

29.26 (5.83)

0.0022

0.001

FPG (mg/dL)

44

86.61 (15.23)

44

96.36 (12.01)

< 0.0001

27

110.56 (14.55)

< 0.0001

< 0.0001

1hPG (mg/dL)

41

127.93 (33.24)

44

189.86 (34.56)

< 0.0001

27

233.15 (27.42)

< 0.0001

< 0.0001#

2hPG (mg/dL)

44

100.89 (22.34)

44

161.36 (17.63)

< 0.0001

27

238.78 (39.21)

< 0.0001

< 0.0001

HbA1c (%)

44

5.8 (0.38)

44

6.2 (0.41)

< 0.0001

27

6.64 (0.6)

< 0.0001

< 0.0001

INS (mIU/L)

42

16.61 (21.05)

44

18.27 (23.1)

0.0183

25

21.04 (20.18)

0.0049

0.0021

HOMA-IR

42

3.43 (4.2)

43

4.48 (5.79)

0.006

25

5.9 (5.94)

0.0001

< 0.0001

TC (mg/dL)

44

204.45 (34.68)

44

206.14 (35.43)

0.8196

27

200.41 (32.6)

0.6323

0.7922#

HDL (mg/dL)

44

57.52 (12.51)

44

51.8 (12.82)

0.0369

27

51.96 (12.89)

0.0765

0.0719#

LDL (mg/dL)

44

125.68 (27.84)

44

130.28 (30.66)

0.457

27

123.13 (27.62)

0.7187

0.5674#

TAG (mg/dL)

44

106.27 (55.95)

44

120.25 (49.68)

0.1414

27

126.59 (62.9)

0.1963

0.0995

m-ALB (mg/dL)

42

7.84 (10.36)

38

26.49 (67.67)

0.0117

25

18.19 (32.1)

0.0252

0.005

miR-21 (a.u.)

39

0.014 (0.01)

43

0.05 (0.056)

< 0.0001

27

0.026 (0.021)

0.0173

< 0.0001

ROS (μmol/min)

40

0.18 (0.01)

29

0.2 (0.01)

< 0.0001

25

0.22 (0.01)

< 0.0001

< 0.0001

SOD2 (pg/mL)

29

3532 (818.6)

25

2489.7 (1274.9)

0.0002

25

1929.4 (830.7)

< 0.0001

< 0.0001#

HNE (μg/mL)

37

4.94 (3.66)

39

7.83 (8.6)

0.1309

27

13.37 (8.78)

< 0.0001

< 0.0001

  1. The italic and bolditalic values are statistical significance
  2. BMI, body mass index; FPG, fasting plasma glucose; 1hPG, 1-hour plasma glucose; 2hPG, 2-hour plasma glucose; HbA1c, glycated hemoglobin A1c; INS, insulinemia; HOMA-IR, homeostatic model assessment for insulin resistance; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low density lipoprotein; TAG, triacylglycerol; m-ALB, microalbuminuria; miR-21, microRNA-21; HNE, hydroxynonenal; SOD2, superoxide dismutase 2; ROS, reactive oxygen species
  3. * Kruskal–Wallis test; #F test
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Cardiovascular Diabetology

ISSN: 1475-2840