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Table 1 Characteristic baseline of subjects

From: Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

  NGT IGT T2 Overall
n %male n %male p (vs NG) n %male p (vs NG) p*
Sex 44   44   0.085 27   0.8 0.19
F 29 65.91 21 47.73   17 62.96   
M 15 34.09 23 52.27   10 37.04   
  NGT IGT T2 Overall
n Mean (± SD) n Mean (± SD) p (vs NG) n Mean (± SD) p (vs NG) p*
Age (years) 44 59.3 (9.82) 44 61.52 (12.7) 0.2743 27 61.69 (7.59) 0.6886 0.283
BMI (kg/m2) 44 25.11 (3.32) 44 27.02 (3.61) 0.029 27 29.26 (5.83) 0.0022 0.001
FPG (mg/dL) 44 86.61 (15.23) 44 96.36 (12.01) <0.0001 27 110.56 (14.55) <0.0001 <0.0001
1hPG (mg/dL) 41 127.93 (33.24) 44 189.86 (34.56) <0.0001 27 233.15 (27.42) <0.0001 <0.0001#
2hPG (mg/dL) 44 100.89 (22.34) 44 161.36 (17.63) <0.0001 27 238.78 (39.21) <0.0001 <0.0001
HbA1c (%) 44 5.8 (0.38) 44 6.2 (0.41) <0.0001 27 6.64 (0.6) <0.0001 <0.0001
INS (mIU/L) 42 16.61 (21.05) 44 18.27 (23.1) 0.0183 25 21.04 (20.18) 0.0049 0.0021
HOMA-IR 42 3.43 (4.2) 43 4.48 (5.79) 0.006 25 5.9 (5.94) 0.0001 <0.0001
TC (mg/dL) 44 204.45 (34.68) 44 206.14 (35.43) 0.8196 27 200.41 (32.6) 0.6323 0.7922#
HDL (mg/dL) 44 57.52 (12.51) 44 51.8 (12.82) 0.0369 27 51.96 (12.89) 0.0765 0.0719#
LDL (mg/dL) 44 125.68 (27.84) 44 130.28 (30.66) 0.457 27 123.13 (27.62) 0.7187 0.5674#
TAG (mg/dL) 44 106.27 (55.95) 44 120.25 (49.68) 0.1414 27 126.59 (62.9) 0.1963 0.0995
m-ALB (mg/dL) 42 7.84 (10.36) 38 26.49 (67.67) 0.0117 25 18.19 (32.1) 0.0252 0.005
miR-21 (a.u.) 39 0.014 (0.01) 43 0.05 (0.056) <0.0001 27 0.026 (0.021) 0.0173 <0.0001
ROS (μmol/min) 40 0.18 (0.01) 29 0.2 (0.01) <0.0001 25 0.22 (0.01) <0.0001 <0.0001
SOD2 (pg/mL) 29 3532 (818.6) 25 2489.7 (1274.9) 0.0002 25 1929.4 (830.7) <0.0001 <0.0001#
HNE (μg/mL) 37 4.94 (3.66) 39 7.83 (8.6) 0.1309 27 13.37 (8.78) <0.0001 <0.0001
  1. The italic and bolditalic values are statistical significance
  2. BMI, body mass index; FPG, fasting plasma glucose; 1hPG, 1-hour plasma glucose; 2hPG, 2-hour plasma glucose; HbA1c, glycated hemoglobin A1c; INS, insulinemia; HOMA-IR, homeostatic model assessment for insulin resistance; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low density lipoprotein; TAG, triacylglycerol; m-ALB, microalbuminuria; miR-21, microRNA-21; HNE, hydroxynonenal; SOD2, superoxide dismutase 2; ROS, reactive oxygen species
  3. * Kruskal–Wallis test; #F test