Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease

Liu, Huan; Lyu, Yongnan; Li, Di; Cui, Yan; Huang, Yun; Dai, Wen; Li, Yan

doi:10.1186/s12933-019-0823-3

Cardiovascular Diabetology

Table 2 Adjusted association between testosterone and GDF-15 levels in the total sample and across categories of hs-CRP, WBC, NEU, neutrophil to lymphocyte ratio, glucose, HDL-c, and LDL-c and whether had hypertension, diabetes, and underwent PCI subgroups

From: Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease

Variable	Unstandardized coefficient (B)	Standardized (B)	95% CI for B	P for trend
Total	− 41.598	− 0.145	− 62.520 to − 20.676	< 0.001
Hypertension
CAD without hypertension	− 55.676	− 0.182	− 103.221 to − 8.132	0.022
CAD with hypertension	− 50.098	− 0.177	− 86.648 to − 13.548	0.007
Diabetes
CAD without diabetes	− 42.299	− 0.149	− 73.706 to − 10.893	0.008
CAD with diabetes	− 99.626	− 0.298	− 173.457 to − 25.795	0.009
PCI
CAD without PCI	− 42.809	− 0.158	− 90.698 to 5.079	0.079
CAD with PCI	− 67.819	− 0.215	− 105.559 to − 30.080	< 0.001
hs-CRP
Lower value (< 1.85 mg/dL)	− 30.174	− 0.121	− 69.087 to 8.738	0.128
Higher value (> 1.85 mg/dL)	− 64.611	− 0.201	− 114.637 to − 14.585	0.012
WBC
Lower value (< 7.25 (10⁹/L))	− 42.226	− 0.162	− 78.957 to − 5.496	0.024
Higher value (> 7.25 (10⁹/L))	− 60.663	− 0.178	− 109.975 to − 11.352	0.016
NEU
Lower value (< 4.62 (10⁹/L))	− 31.812	− 0.119	− 69.644 to 6.019	0.099
Higher value (> 4.62 (10⁹/L))	− 76.342	− 0.238	− 121.420 to − 31.265	0.001
Neutrophil to lymphocyte ratio
Lower value (< 2.83)	− 25.081	− 0.094	− 63.680 to 13.517	0.201
Higher value (> 2.83)	− 86.434	− 0.267	− 130.118 to − 42.750	< 0.001
Glucose
Lower value (< 5.58 mmol/L)	− 26.029	− 0.099	− 65.959 to 13.901	0.200
Higher value (> 5.58 mmol/L)	− 76.395	− 0.234	− 119.955 to − 32.834	0.001
UA
Lower value (< 388 umol/L)	− 67.095	− 0.214	− 111.406 to − 22.785	0.003
Higher value (> 388 umol/L)	− 52.117	− 0.194	− 92.312 to − 11.922	0.011
HDL-c
Lower value (< 0.91 mmol/L)	− 56.000	− 0.190	− 98.395 to − 13.604	0.010
Higher value (> 0.91 mmol/L)	− 40.376	− 0.135	− 86.511 to 5.759	0.086
LDL-c
Lower value (< 2.16 mmol/L)	− 55.056	− 0.191	− 98.330 to − 11.782	0.013
Higher value (> 2.16 mmol/L)	− 49.148	− 0.159	− 95.688 to − 2.607	0.039

hs-CRP high-sensitivity C-reactive protein, WBC white blood cell, NEU neutrophil, UA uric acid, HDL-c high-density lipoprotein cholesterol, LDL-c low-density lipoprotein cholesterol, GDF-15 growth differentiation factor-15, PCI percutaneous coronary intervention

Back to article page

ISSN: 1475-2840

Contact us

Submission enquiries: journalsubmissions@springernature.com