Fig. 4

Coronary flow was studied over time in lean, ob/ob^−/− treated and untreated mice using non-invasive transthoracic ultrasound. Coronary flow velocity reserve (CFVR) a was calculated as the ratio of b coronary hyperemic and c basal flow velocities. Statistical significance between groups was tested using Anova, and where there were differences Turkey’s multiple comparison test was carried out. Values are presented as mean with standard deviation, where *p < 0.05 and **p < 0.01 for significant difference between lean controls and ob/ob^−/− groups. ^‡p ≤ 0.05 for ob/ob^−/− treated and untreated group