Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium

Table 1 Clinical characteristics and cardiac function measured by echocardiography in study participants

Sample ID	Age (years)	Sex	Diabetes duration (years)	HbA1c (mmol/mol)	BMI (Kg/m²)	Systolic blood pressure (mmHg)	Diastoic blood pressure (mmHg)	EF (%)	E/e’	E/A	IVSd (cm)	LVIDd (cm)	LVIDs (cm)	LVPWd (cm)	LV mass (gm)
Non-diabetic-IHD
148	54	M	–	27	24.78	115	70	54	5.38	1.06	1.3	5.0	–	1.3	262
132	79	M	–	39	27.18	118	68	33	1.75	14	1.2	5.3	4.4	0.8	200
154	81	M	–	40	23.27	140	70	50	–	0.63	1.0	5.4	3.2	1.2	235
286	80	M	–	35	26.61	107	66	62.6	14.15	0.91	1.1	4.6	3.1	1.0	170
235	62	M	–	30	28.11	148	90	57	–	0.49	1.3	5.0	3.5	1.2	248
134	68	M	–	N/A	32.15	115	60	56	21.32	0.7	1.4	3.6	2.4	1.2	160
238	79	F	–	37	21.72	156	86	73	12.73	0.61	1.3	3.7	2.1	1.2	157
237	61	M	–	33	30.86	160	72	44	9.71	1.15	1.6	4.6	3.7	1.1	243
173	57	M	–	N/A	32.19	115	62	45	9.72	0.65	1.0	6.1	4.3	0.8	222
236	78	M	–	N/A	28.20	126	78	52.4	N/A	N/A	1.3	4.6	3.5	1.4	243
Average	69.90			34.43	27.51	130.00	72.20	52.70	10.68	2.24	1.25	4.79	3.36	1.12	214
SD	10.65			4.76	3.58	19.33	9.77	10.91	6.31	4.41	0.18	0.76	0.77	0.20	39.4
Diabetic-IHD
221	54	M	6	84	26.73	130	72	55	7.85	1.06	1.1	5.1	3.3	1.3	N/A
293	54	M	3	47	34.66	115	65	66.4	8.77	0.71	1.2	5.0	3	1.2	234
174	79	M	58	73	20.98	120	50	28	15.59	0.51	1.4	5.3	4.2	1.2	287
177	81	M	10	39	21.07	130	95	27		0.76	1.2	5.0	4.1	1.3	248
229	85	M	28	42	24.16	105	60	67	22.02	0.77			2.8
190	80	M	8	48	30.61	135	75	52	9.6	0.61	1.6	4.1	3.2	1.4	241
92	62	M	4	53	36.50	138	78	54	–	–	1.7	3.8	3.1	1.3	217
120	68	M	2	51	26.85	120	80	53	7.71	0.62	1.7	4.6	2.1	1.6	330
164	61	M	30	50	33.02	130	75	52	10	0.73
301	78	M	11	36	32.81	128	78	72	–	0.66	1.8	4.0	2.3	1.3	245
Average	70.20		16.00	52.3**	28.74	125.10	72.80	52.64	11.65	0.71	1.51*	4.54	3.00	1.33*	257
SD	11.79		17.76	15.04	5.59	10.02	12.26	15.07	5.30	0.15	0.27	0.57	0.71	0.13	38.4
Non-diabetic vs. diabetic	0.9531			0.009	0.565	0.486	0.905	0.992	0.761	0.314	0.023	0.0231	0.4799	0.322	0.1204

IHD ischaemic heart disease, BMI body mass index, EF ejection fraction, IVSD intraventricular septal thickness at the end of diastole, LVIDd left ventricular (LV) internal diameter at the end of diastole, LVIDs LV internal diameter at the end of systole, LVPWd LV posterior wall thickness at the end of diastole, N/A data not available
*P < 0.5 vs. non-diabetic IHD

ISSN: 1475-2840