Table 4 Improvements in risk prediction after adding carotid atherosclerosis parameters to a standard risk factor model
Outcomes | C-statistic | Integrated discrimination improvement index | ||||
|---|---|---|---|---|---|---|
Carotid atherosclerosis parameters | AUC standard modela | Improvement in AUC | p-value | Absolute | Relative (%) | p-value |
Total cardiovascular events | 0.769 | Â | Â | Â | Â | Â |
 CCA-IMT (continuous) |  | 0.00002 (− 0.009 to 0.009) | 0.99 | 0.008 (− 0.001 to 0.017) | 5.4 | 0.082 |
 CB-IMT (continuous) |  | 0.006 (− 0.005 to 0.018) | 0.27 | 0.009 (− 0.001 to 0.018) | 6.6 | 0.069 |
 ICA-IMT (continuous) |  | 0.006 (− 0.006 to 0.017) | 0.33 | 0.005 (− 0.005 to 0.016) | 3.6 | 0.32 |
 CCA-IMT (tertiles) |  | 0.003 (− 0.009 to 0.014) | 0.67 | 0.009 (0.002 to 0.016) | 5.5 | 0.016 |
 CB-IMT (tertiles) |  | 0.009 (− 0.006 to 0.024) | 0.25 | 0.011 (0.001 to 0.022) | 8.4 | 0.036 |
 ICA-IMT (tertiles) |  | 0.003 (− 0.006 to 0.013) | 0.48 | 0.001 (− 0.006 to 0.008) | 1.2 | 0.72 |
 CCA-IMT (> 1.0 mm) |  | 0.0001 (− 0.004 to 0.004) | 0.98 | 0.002 (− 0.001 to 0.004) | 1.2 | 0.18 |
 CB-IMT (> 1.2 mm) |  | 0.007 (− 0.007 to 0.021) | 0.33 | 0.010 (0 to 0.020) | 7.8 | 0.050 |
 ICA-IMT (> 0.8 mm) |  | 0.009 (− 0.007 to 0.024) | 0.29 | 0.008 (− 0.003 to 0.018) | 5.4 | 0.17 |
 Carotid plaque score (≥ 3 points) |  | 0.009 (− 0.006 to 0.023) | 0.24 | 0.014 (0.001 to 0.027) | 7.8 | 0.040 |
Renal composite | 0.644 | Â | Â | Â | Â | Â |
 ICA-IMT (continuous) |  | 0.018 (− 0.007 to 0.042) | 0.16 | 0.010 (− 0.001 to 0.020) | 18.5 | 0.070 |
 ICA-IMT (tertiles) |  | 0.009 (− 0.007 to 0.026) | 0.27 | 0.002 (− 0.004 to 0.008) | 1.9 | 0.57 |
 ICA-IMT (> 0.8 mm) |  | 0.022 (− 0.006 to 0.049) | 0.12 | 0.010 (− 0.001 to 0.020) | 14.8 | 0.071 |
 Carotid plaque score (≥ 3 points) |  | 0.014 (− 0.010 to 0.038) | 0.24 | 0.010 (0.0001 to 0.019) | 17.9 | 0.049 |