Prognostic impact of carotid intima-media thickness and carotid plaques on the development of micro- and macrovascular complications in individuals with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study

Claudia R. L. Cardoso; Guilherme C. Salles; Nathalie C. Leite; Gil F. Salles

doi:10.1186/s12933-019-0809-1

Table 3 Results of multivariate analyses for the risks associations between baseline early carotid atherosclerosis parameters and incident cardiovascular and renal events and mortality outcomes during follow-up

From: Prognostic impact of carotid intima-media thickness and carotid plaques on the development of micro- and macrovascular complications in individuals with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study

Outcomes	Age and sex adjusted		Multivariate adjusted^a
Carotid atherosclerosis parameters	HR (95% CI)	p-value	HR (95% CI)	p-value
Total cardiovascular events (n = 116)
CCA-IMT (0.1 mm increment)	1.30 (1.15–1.46)	< 0.001	1.15 (1.02–1.31)	0.024
CB-IMT (0.1 mm increment)	1.31 (1.14–1.51)	< 0.001	1.15 (1.00–1.33)	0.058
ICA-IMT (0.1 mm increment)	1.31 (1.14–1.51)	< 0.001	1.18 (1.02–1.37)	0.023
CCA-IMT (highest vs. lowest tertile)	2.89 (1.64–5.10)	< 0.001	1.83 (1.01–3.32)	0.045
CB-IMT (highest vs. lowest tertile)	2.75 (1.59–4.75)	< 0.001	1.83 (1.03–3.23)	0.039
ICA-IMT (highest vs. lowest tertile)	2.13 (1.24–3.65)	0.006	1.53 (0.88–2.67)	0.13
CCA-IMT (> 1.0 mm)	1.54 (1.02–2.32)	0.041	1.22 (0.80–1.86)	0.36
CB-IMT (> 1.2 mm)	2.25 (1.41–3.60)	0.001	1.72 (1.05–2.80)	0.030
ICA-IMT (> 0.8 mm)	2.12 (1.38–3.25)	0.001	1.70 (1.09–2.66)	0.020
Carotid plaque score (≥ 3 points)	2.27 (1.51–3.43)	< 0.001	1.51 (0.97–2.33)	0.065
All-cause mortality (n = 115)
CCA-IMT (0.1 mm increment)	1.16 (1.02–1.32)	0.024	1.05 (0.92–1.20)	0.47
CB-IMT (0.1 mm increment)	1.07 (0.93–1.24)	0.36	0.97 (0.83–1.13)	0.65
ICA-IMT (0.1 mm increment)	1.07 (0.94–1.22)	0.32	1.02 (0.89–1.17)	0.79
CCA-IMT (highest vs. lowest tertile)	1.36 (0.81–2.29)	0.24	0.96 (0.56–1.63)	0.87
CB-IMT (highest vs. lowest tertile)	1.26 (0.77–2.04)	0.36	0.95 (0.57–1.59)	0.85
ICA-IMT (highest vs. lowest tertile)	1.16 (0.72–1.89)	0.54	1.05 (0.63–1.74)	0.86
CCA-IMT (> 1.0 mm)	1.25 (0.83–1.88)	0.28	1.08 (0.71–1.63)	0.72
CB-IMT (> 1.2 mm)	1.23 (0.80–1.88)	0.34	0.98 (0.63–1.53)	0.92
ICA-IMT (> 0.8 mm)	1.08 (0.73–1.60)	0.69	0.98 (0.65–1.48)	0.92
Carotid plaque score (≥ 3 points)	1.95 (1.30–2.91)	0.001	1.39 (0.90–2.14)	0.14
Renal composite outcome (n = 156)
CCA-IMT (0.1 mm increment)	1.17 (1.05–1.30)	0.005	1.11 (0.99–1.25)	0.069
CB-IMT (0.1 mm increment)	1.16 (1.03–1.30)	0.013	1.12 (0.99–1.27)	0.066
ICA-IMT (0.1 mm increment)	1.18 (1.06–1.32)	0.003	1.15 (1.01–1.29)	0.028
CCA-IMT (highest vs. lowest tertile)	1.48 (0.94–2.31)	0.088	1.16 (0.72–1.65)	0.71
CB-IMT (highest vs. lowest tertile)	1.55 (1.03–2.35)	0.037	1.38 (0.89–2.14)	0.15
ICA-IMT (highest vs. lowest tertile)	1.41 (0.92–2.16)	0.12	1.16 (0.74–1.82)	0.52
CCA-IMT (> 1.0 mm)	1.37 (0.98–1.94)	0.069	1.22 (0.85–1.74)	0.28
CB-IMT (> 1.2 mm)	1.31 (0.92–1.85)	0.13	1.22 (0.84–1.76)	0.29
ICA-IMT (> 0.8 mm)	1.69 (1.20–2.39)	0.003	1.55 (1.08–2.23)	0.016
Carotid plaque score (≥ 3 points)	1.68 (1.15–2.46)	0.007	1.63 (1.09–2.43)	0.017

Values are hazard ratios and their 95% confidence intervals
HR hazard ratio, CI confidence interval, CCA-IMT common carotid artery intima-media thickness, CB-IMT carotid bifurcation intima-media thickness, ICA-IMT internal carotid artery intima-media thickness
^aAdjusted for age, sex, BMI, smoking status, physical activity, diabetes duration, mean clinic systolic blood pressure during the 1st year of follow-up, number of anti-hypertensive drugs in use, presence of micro- and macrovascular complications at baseline (in analyses of renal outcomes, presence of diabetic nephropathy was added), mean HbA_1c, HDL- and LDL-cholesterol during the 1st year of follow-up, and use of insulin and statins

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