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Table 5 Metabolite ratios correlated with blood lipids and serum Hp levels in T2DM patients

From: Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Metabolite ratios Total cholesterol Triglycerides HDL-C LDL-C Serum Hp Carotid IMT Carotid IAD
Asn/PC ae C32:2 − 0.949 ± 0.290 0.061 ± 0.066 − 0.006 ± 0.137 0.277 ± 0.164 0.033 ± 0.012 0.344 ± 0.114 − 0.230 ± 0.196
0.0015 0.3555 0.9626 0.0942 0.0059 0.0032 0.2433
Asp/PC ae C32:2 − 0.723 ± 0.367 0.047 ± 0.083 − 0.153 ± 0.173 0.290 ± 0.207 0.041 ± 0.015 0.361 ± 0.144 − 0.516 ± 0.248
0.0513 0.5726 0.3789 0.1651 0.0059 0.0138 0.0396
Glu/PC ae C32:2 − 1.121 ± 0.400 0.218 ± 0.091 − 0.113 ± 0.189 0.554 ± 0.226 0.039 ± 0.016 0.252 ± 0.157 − 0.817 ± 0.270
0.0061 0.0183 0.5520 0.0160 0.0160 0.1125 0.0031
Ile/PC ae C32:2 − 1.084 ± 0.329 0.241 ± 0.075 − 0.037 ± 0.156 0.473 ± 0.186 0.031 ± 0.013 0.170 ± 0.129 − 0.534 ± 0.222
0.0014 0.0017 0.8101 0.0124 0.0222 0.1933 0.0180
Val/PC ae C32:2 − 1.011 ± 0.300 0.189 ± 0.068 − 0.071 ± 0.142 0.499 ± 0.169 0.031 ± 0.012 0.183 ± 0.118 − 0.569 ± 0.202
0.0010 0.0064 0.6197 0.0039 0.0116 0.1241 0.0059
  1. Multiple linear regression analysis was used to perform the analysis after adjusting for age, sex and body mass index with total cholesterol, triglycerides, HDL-C, LDL-C, serum Hp level tertiles, carotid IMT and IAD as independent variables. β ± SE and P values are shown in table
  2. T2DM type 2 diabetes mellitus, Asn asparagine, Asp aspartate, Glu glutamic acid, Ile isoleucine, Val valine, Hp haptoglobin, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, IMT intima-media thickness, IAD inter-adventitial diameter
  3. P values < 0.05 are shown in italic