Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Table 5 Metabolite ratios correlated with blood lipids and serum Hp levels in T2DM patients

Metabolite ratios	Total cholesterol	Triglycerides	HDL-C	LDL-C	Serum Hp	Carotid IMT	Carotid IAD
Asn/PC ae C32:2	− 0.949 ± 0.290	0.061 ± 0.066	− 0.006 ± 0.137	0.277 ± 0.164	0.033 ± 0.012	0.344 ± 0.114	− 0.230 ± 0.196
Asn/PC ae C32:2	0.0015	0.3555	0.9626	0.0942	0.0059	0.0032	0.2433
Asp/PC ae C32:2	− 0.723 ± 0.367	0.047 ± 0.083	− 0.153 ± 0.173	0.290 ± 0.207	0.041 ± 0.015	0.361 ± 0.144	− 0.516 ± 0.248
Asp/PC ae C32:2	0.0513	0.5726	0.3789	0.1651	0.0059	0.0138	0.0396
Glu/PC ae C32:2	− 1.121 ± 0.400	0.218 ± 0.091	− 0.113 ± 0.189	0.554 ± 0.226	0.039 ± 0.016	0.252 ± 0.157	− 0.817 ± 0.270
Glu/PC ae C32:2	0.0061	0.0183	0.5520	0.0160	0.0160	0.1125	0.0031
Ile/PC ae C32:2	− 1.084 ± 0.329	0.241 ± 0.075	− 0.037 ± 0.156	0.473 ± 0.186	0.031 ± 0.013	0.170 ± 0.129	− 0.534 ± 0.222
Ile/PC ae C32:2	0.0014	0.0017	0.8101	0.0124	0.0222	0.1933	0.0180
Val/PC ae C32:2	− 1.011 ± 0.300	0.189 ± 0.068	− 0.071 ± 0.142	0.499 ± 0.169	0.031 ± 0.012	0.183 ± 0.118	− 0.569 ± 0.202
Val/PC ae C32:2	0.0010	0.0064	0.6197	0.0039	0.0116	0.1241	0.0059

Multiple linear regression analysis was used to perform the analysis after adjusting for age, sex and body mass index with total cholesterol, triglycerides, HDL-C, LDL-C, serum Hp level tertiles, carotid IMT and IAD as independent variables. β ± SE and P values are shown in table
T2DM type 2 diabetes mellitus, Asn asparagine, Asp aspartate, Glu glutamic acid, Ile isoleucine, Val valine, Hp haptoglobin, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, IMT intima-media thickness, IAD inter-adventitial diameter
P values < 0.05 are shown in italic

ISSN: 1475-2840