Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Wang, Shiyun; Wang, Jie; Zhang, Rong; Zhao, Aihua; Zheng, Xiaojiao; Yan, Dandan; Jiang, Feng; Jia, Wei; Hu, Cheng; Jia, Weiping

doi:10.1186/s12933-019-0808-2

Cardiovascular Diabetology

Table 3 Blood metabolites correlated with blood lipids and serum Hp levels in T2DM patients

From: Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Metabolites	Total cholesterol	Triglycerides	HDL-C	LDL-C	Serum Hp	Carotid IMT	Carotid IAD
Acylcarnitines (μM)
C16-OH	0.017 ± 0.011	− 0.002 ± 0.002	− 0.011 ± 0.005	− 0.008 ± 0.006	− 0.001 ± 0.001	0.012 ± 0.004	− 0.002 ± 0.007
C16-OH	0.1099	0.4393	0.0270	0.1690	0.0452	0.0074	0.7911
Lyso-phosphatidylcholines (μM)
Lyso-PC a C20:3	− 0.316 ± 1.027	0.834 ± 0.233	1.073 ± 0.485	− 0.202 ± 0.580	− 0.092 ± 0.041	− 0.173 ± 0.404	0.511 ± 0.693
Lyso-PC a C20:3	0.7588	0.0005	0.0290	0.7286	0.0272	0.6698	0.4621
Phosphatidylcholines (μM)
PC aa C32:0	10.436 ± 4.062	1.295 ± 0.921	1.681 ± 1.918	− 2.026 ± 2.294	− 0.356 ± 0.163	2.011 ± 1.597	3.939 ± 2.741
PC aa C32:0	0.0116	0.1626	0.3828	0.3791	0.0308	0.2106	0.1536
PC aa C32:1	− 4.69 ± 5.368	5.805 ± 1.217	6.355 ± 2.534	5.062 ± 3.032	− 0.458 ± 0.215	− 0.323 ± 2.11	2.788 ± 3.622
PC aa C32:1	0.3843	< 0.0001	0.0137	0.0979	0.0356	0.8787	0.4432
PC aa C34:1	− 11.594 ± 75.657	92.794 ± 17.157	89.522 ± 35.716	57.696 ± 42.730	− 7.002 ± 3.033	− 2.744 ± 29.739	34.784 ± 51.050
PC aa C34:1	0.8785	< 0.0001	0.0137	0.1798	0.0229	0.9267	0.4971
PC aa C34:4	0.095 ± 0.634	0.617 ± 0.144	0.824 ± 0.299	0.145 ± 0.358	− 0.054 ± 0.025	− 0.193 ± 0.249	− 0.092 ± 0.428
PC aa C34:4	0.8806	< 0.0001	0.0070	0.6861	0.0370	0.4397	0.8303
PC aa C36:3	14.350 ± 36.596	49.046 ± 8.299	69.044 ± 17.276	− 5.324 ± 20.669	− 3.283 ± 1.467	− 9.846 ± 14.385	10.639 ± 24.693
PC aa C36:3	0.6957	< 0.0001	0.0001	0.7972	0.0273	0.4951	0.6674
PC ae C32:1	0.972 ± 0.740	− 0.094 ± 0.168	0.437 ± 0.349	0.072 ± 0.418	− 0.078 ± 0.030	− 0.054 ± 0.291	0.964 ± 0.499
PC ae C32:1	0.1918	0.5766	0.2136	0.8629	0.0095	0.8543	0.0561
PC ae C32:2	0.411 ± 0.196	− 0.033 ± 0.045	0.081 ± 0.093	− 0.136 ± 0.111	− 0.028 ± 0.008	− 0.073 ± 0.077	0.318 ± 0.133
PC ae C32:2	0.0390	0.4613	0.3837	0.2241	0.0005	0.3475	0.0182
PC ae C34:1	2.502 ± 1.734	0.505 ± 0.393	1.905 ± 0.819	− 0.554 ± 0.979	− 0.171 ± 0.070	0.759 ± 0.682	1.971 ± 1.170
PC ae C34:1	0.1519	0.2021	0.0218	0.5728	0.0155	0.2678	0.0950
PC ae C36:5	10.917 ± 4.572	− 1.698 ± 1.037	2.473 ± 2.158	− 2.333 ± 2.582	− 0.389 ± 0.183	− 2.415 ± 1.797	0.752 ± 3.085
PC ae C36:5	0.0187	0.1044	0.2544	0.3683	0.0360	0.1818	0.8079
PC ae C38:6	5.671 ± 3.030	− 0.272 ± 0.687	2.976 ± 1.431	− 0.609 ± 1.711	− 0.252 ± 0.121	− 1.226 ± 1.191	0.707 ± 2.045
PC ae C38:6	0.0640	0.6927	0.0399	0.7227	0.0407	0.3058	0.7303
PC ae C40:5	2.559 ± 1.247	− 0.166 ± 0.283	0.694 ± 0.589	− 0.934 ± 0.704	− 0.111 ± 0.050	− 0.314 ± 0.490	0.182 ± 0.841
PC ae C40:5	0.0426	0.5596	0.2413	0.1877	0.0286	0.5231	0.8287
Amino acids (μM)
His	− 150.758 ± 41.991	37.965 ± 9.523	39.971 ± 19.823	65.304 ± 23.716	− 4.080 ± 1.683	6.756 ± 16.506	− 17.531 ± 28.334
His	0.0005	0.0001	0.0463	0.0069	0.0170	0.6831	0.5374
Phe	− 36.314 ± 54.241	13.975 ± 12.301	− 7.065 ± 25.606	33.892 ± 30.634	− 4.385 ± 2.175	57.330 ± 21.321	41.455 ± 36.600
Phe	0.5046	0.2584	0.7831	0.2711	0.0462	0.0083	0.2599

Multiple linear regression analysis was used to perform the analysis after adjusting for age, sex and body mass index with total cholesterol, triglycerides, HDL-C, LDL-C, serum Hp level tertiles, carotid IMT and IAD as independent variables. β ± SE and P values are shown in table
T2DM type 2 diabetes mellitus, Hp haptoglobin, His histidine, Phe phenylalanine, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, IMT intima-media thickness, IAD inter-adventitial diameter
P values < 0.05 are shown in italic

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