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Table 3 Blood metabolites correlated with blood lipids and serum Hp levels in T2DM patients

From: Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Metabolites Total cholesterol Triglycerides HDL-C LDL-C Serum Hp Carotid IMT Carotid IAD
Acylcarnitines (μM)
 C16-OH 0.017 ± 0.011 − 0.002 ± 0.002 − 0.011 ± 0.005 − 0.008 ± 0.006 − 0.001 ± 0.001 0.012 ± 0.004 − 0.002 ± 0.007
0.1099 0.4393 0.0270 0.1690 0.0452 0.0074 0.7911
Lyso-phosphatidylcholines (μM)
 Lyso-PC a C20:3 − 0.316 ± 1.027 0.834 ± 0.233 1.073 ± 0.485 − 0.202 ± 0.580 − 0.092 ± 0.041 − 0.173 ± 0.404 0.511 ± 0.693
0.7588 0.0005 0.0290 0.7286 0.0272 0.6698 0.4621
Phosphatidylcholines (μM)
 PC aa C32:0 10.436 ± 4.062 1.295 ± 0.921 1.681 ± 1.918 − 2.026 ± 2.294 − 0.356 ± 0.163 2.011 ± 1.597 3.939 ± 2.741
0.0116 0.1626 0.3828 0.3791 0.0308 0.2106 0.1536
 PC aa C32:1 − 4.69 ± 5.368 5.805 ± 1.217 6.355 ± 2.534 5.062 ± 3.032 − 0.458 ± 0.215 − 0.323 ± 2.11 2.788 ± 3.622
0.3843 < 0.0001 0.0137 0.0979 0.0356 0.8787 0.4432
 PC aa C34:1 − 11.594 ± 75.657 92.794 ± 17.157 89.522 ± 35.716 57.696 ± 42.730 − 7.002 ± 3.033 − 2.744 ± 29.739 34.784 ± 51.050
0.8785 < 0.0001 0.0137 0.1798 0.0229 0.9267 0.4971
 PC aa C34:4 0.095 ± 0.634 0.617 ± 0.144 0.824 ± 0.299 0.145 ± 0.358 − 0.054 ± 0.025 − 0.193 ± 0.249 − 0.092 ± 0.428
0.8806 < 0.0001 0.0070 0.6861 0.0370 0.4397 0.8303
 PC aa C36:3 14.350 ± 36.596 49.046 ± 8.299 69.044 ± 17.276 − 5.324 ± 20.669 − 3.283 ± 1.467 − 9.846 ± 14.385 10.639 ± 24.693
0.6957 < 0.0001 0.0001 0.7972 0.0273 0.4951 0.6674
 PC ae C32:1 0.972 ± 0.740 − 0.094 ± 0.168 0.437 ± 0.349 0.072 ± 0.418 − 0.078 ± 0.030 − 0.054 ± 0.291 0.964 ± 0.499
0.1918 0.5766 0.2136 0.8629 0.0095 0.8543 0.0561
 PC ae C32:2 0.411 ± 0.196 − 0.033 ± 0.045 0.081 ± 0.093 − 0.136 ± 0.111 − 0.028 ± 0.008 − 0.073 ± 0.077 0.318 ± 0.133
0.0390 0.4613 0.3837 0.2241 0.0005 0.3475 0.0182
 PC ae C34:1 2.502 ± 1.734 0.505 ± 0.393 1.905 ± 0.819 − 0.554 ± 0.979 − 0.171 ± 0.070 0.759 ± 0.682 1.971 ± 1.170
0.1519 0.2021 0.0218 0.5728 0.0155 0.2678 0.0950
 PC ae C36:5 10.917 ± 4.572 − 1.698 ± 1.037 2.473 ± 2.158 − 2.333 ± 2.582 − 0.389 ± 0.183 − 2.415 ± 1.797 0.752 ± 3.085
0.0187 0.1044 0.2544 0.3683 0.0360 0.1818 0.8079
 PC ae C38:6 5.671 ± 3.030 − 0.272 ± 0.687 2.976 ± 1.431 − 0.609 ± 1.711 − 0.252 ± 0.121 − 1.226 ± 1.191 0.707 ± 2.045
0.0640 0.6927 0.0399 0.7227 0.0407 0.3058 0.7303
 PC ae C40:5 2.559 ± 1.247 − 0.166 ± 0.283 0.694 ± 0.589 − 0.934 ± 0.704 − 0.111 ± 0.050 − 0.314 ± 0.490 0.182 ± 0.841
0.0426 0.5596 0.2413 0.1877 0.0286 0.5231 0.8287
Amino acids (μM)
 His − 150.758 ± 41.991 37.965 ± 9.523 39.971 ± 19.823 65.304 ± 23.716 − 4.080 ± 1.683 6.756 ± 16.506 − 17.531 ± 28.334
0.0005 0.0001 0.0463 0.0069 0.0170 0.6831 0.5374
 Phe − 36.314 ± 54.241 13.975 ± 12.301 − 7.065 ± 25.606 33.892 ± 30.634 − 4.385 ± 2.175 57.330 ± 21.321 41.455 ± 36.600
0.5046 0.2584 0.7831 0.2711 0.0462 0.0083 0.2599
  1. Multiple linear regression analysis was used to perform the analysis after adjusting for age, sex and body mass index with total cholesterol, triglycerides, HDL-C, LDL-C, serum Hp level tertiles, carotid IMT and IAD as independent variables. β ± SE and P values are shown in table
  2. T2DM type 2 diabetes mellitus, Hp haptoglobin, His histidine, Phe phenylalanine, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, IMT intima-media thickness, IAD inter-adventitial diameter
  3. P values < 0.05 are shown in italic