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Table 2 Blood metabolites in subjects grouped by serum Hp levels

From: Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach

Metabolites Low Hp Middle Hp High Hp P value
T2DM (n = 120)
 Acylcarnitines (μM)
  C12:1 0.142 ± 0.042 0.148 ± 0.044 0.116 ± 0.032 0.0017
  C14:1 0.241 ± 0.064 0.229 ± 0.067 0.201 ± 0.048 0.0119
 Lyso-phosphatidylcholines (μM)
  Lyso-PC a C20:3 1.284 ± 0.423 1.050 ± 0.319 1.064 ± 0.332 0.0158
 Phosphatidylcholines (μM)
  PC aa C32:1 5.437 ± 2.670 4.678 ± 1.994 4.128 ± 1.775 0.0398
  PC aa C34:1 109.683 ± 37.529 99.877 ± 34.435 89.110 ± 23.902 0.0117
  PC aa C34:2 323.235 ± 80.457 308.206 ± 90.611 283.969 ± 72.902 0.0456
  PC aa C36:1 22.898 ± 6.344 21.283 ± 4.553 19.615 ± 6.216 0.0041
  PC aa C40:4 2.093 ± 0.646 1.881 ± 0.541 1.809 ± 0.594 0.0458
  PC ae C32:1 1.329 ± 0.294 1.281 ± 0.268 1.171 ± 0.245 0.0364
  PC ae C32:2 0.335 ± 0.088 0.301 ± 0.062 0.281 ± 0.058 0.0094
  PC ae C34:1 3.305 ± 0.712 3.254 ± 0.733 2.902 ± 0.559 0.0270
  PC ae C36:0 0.577 ± 0.180 0.546 ± 0.128 0.470 ± 0.098 0.0055
  PC ae C36:1 4.953 ± 0.948 4.642 ± 0.925 4.417 ± 0.814 0.0327
  PC ae C40:5 2.140 ± 0.418 2.034 ± 0.527 1.871 ± 0.374 0.0329
  PC ae C42:2 0.333 ± 0.080 0.307 ± 0.082 0.287 ± 0.060 0.0443
 Amino acids (μM)
  His 115.000 ± 15.508 111.528 ± 15.191 105.444 ± 14.510 0.0183
  Lys 330.411 ± 57.377 306.053 ± 61.629 300.033 ± 54.178 0.0255
  Trp 65.594 ± 14.239 59.247 ± 13.020 58.258 ± 10.826 0.0238
  Tyr 89.152 ± 19.114 84.488 ± 17.566 79.436 ± 16.558 0.0494
Non-DM (n = 120)
 Acylcarnitines (μM)
  C16:1-OH 0.018 ± 0.004 0.010 ± 0.002 0.013 ± 0.002 0.0440
  C2 6.327 ± 2.720 5.684 ± 1.558 6.773 ± 2.023 0.0385
  C3 0.334 ± 0.109 0.299 ± 0.124 0.386 ± 0.191 0.0294
  C4 0.211 ± 0.075 0.184 ± 0.082 0.225 ± 0.090 0.0209
  C6/C4:1-DC 0.085 ± 0.038 0.083 ± 0.058 0.113 ± 0.074 0.0240
 Lyso-phosphatidylcholines (μM)
  LysoPC a C17:0 1.302 ± 0.361 1.208 ± 0.318 1.115 ± 0.326 0.0463
  LysoPC a C24:0 0.371 ± 0.121 0.312 ± 0.112 0.307 ± 0.120 0.0450
Phosphatidylcholines (μM)
  PC aa C32:3 0.260 ± 0.047 0.239 ± 0.061 0.225 ± 0.059 0.0087
  PC aa C42:2 0.276 ± 0.062 0.289 ± 0.116 0.243 ± 0.070 0.0326
  PC ae C32:2 0.475 ± 0.098 0.453 ± 0.131 0.424 ± 0.089 0.0602
  PC ae C36:2 7.123 ± 1.446 6.882 ± 2.063 6.309 ± 1.124 0.0304
  PC ae C38:0 1.141 ± 0.298 1.062 ± 0.377 0.969 ± 0.252 0.0471
  PC ae C40:1 1.286 ± 0.246 1.164 ± 0.263 1.101 ± 0.189 0.0071
  PC ae C42:1 0.372 ± 0.093 0.347 ± 0.091 0.321 ± 0.071 0.0197
 Amino acids (μM)
  Asp 32.646 ± 5.990 31.854 ± 4.664 36.137 ± 6.343 0.0034
  Trp 75.043 ± 8.173 71.877 ± 9.742 68.875 ± 11.423 0.0244
  Ac-Orn 2.189 ± 0.159 2.239 ± 0.001 1.596 ± 0.941 0.0185
  1. Data are shown as the mean ± standard deviation. P values < 0.05 are shown in table
  2. T2DM type 2 diabetes mellitus,  Non-DM non-diabetes mellitus, Hp haptoglobin, His histidine, Lys lysine, Trp tryptophan, Tyr tyrosine, Asp aspartate, Ac-Orn acyl-ornithine