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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

Fig. 2

Abrogated cardiac remodelling by mAb A treatment is associated with inhibition of mTOR signalling pathway post-MI. a In vivo corrected left ventricle (LV) mass (mg). b Representative blots for mTOR signalling pathway. Densiometric analysis for c phosphorylated mammalian target of rapamycin (p-mTROSer2448)/mTOR, d phosphorylated ribosomal protein S6 kinase (p-P70S6KThr389)/P70S6K, e sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2A)/α-tubulin. Protein bands were normalised for either to their correspondent total protein band or to α-tubulin bands for intra-experiment variation. Data are represented as mean ± SEM. *p < 0.05. n = 6/group. S sham, V vehicle, Ab mAb A, MI myocardial infarction

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