From: Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects
Inclusion criteria | Exclusion criteria |
---|---|
18Â years and older | Undefined type of diabetes or clinical suspicion of non-type 2 diabetes mellitus |
Confirmed diagnosis of type 2 diabetes mellitus at the time of admission | Confirmed pancreatic insufficiency, chronic pancreatitis or previous pancreatic surgery |
Able to understand study procedures | Ongoing steroidal therapy or steroidal therapy in the previous 3Â months |
Willing to participate in the study and to sign the written informed consent | Ongoing calcineurin inhibitor therapy or history of calcineurin inhibitor therapy |
 | Ongoing statin therapy or statin therapy in the previous month |
 | Suspected or confirmed pregnancy |
 | Chronic kidney disease with eGFR below 30 mL/min (according to the CKD-EPI equation) |
 | Previous non-traumatic lower limb amputation |
 | Solid organ or marrow transplant recipient |
 | History or active solid or hematological malignancy |
 | Acute infectious disease at the time of evaluation or in the previous month |
 | Chronic liver disease with a functional status, according to the Child–Pugh classification, of B or above |
 | Hereditary monogenic dyslipidemia (confirmed or suspected) |
 | Congenital disease of platelet function |
 | Acquired or congenital thrombocytopenia |
 | Congenital or acquired hemophilia or coagulation defect |
 | Congenital or acquired thrombophilia |
 | Active autoimmune disease |