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Table 2 Serum biochemical, oxidative stress and inflammation examination

From: Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits

  CON group (n = 10) DM group (n = 10) DM-A group (n = 10) P value
Glucose (mmol/L) 4.98 ± 0.45 14.12 ± 1.69** 11.03 ± 2.01**# < 0.001
INS (mmol/L) 17.84 ± 2.57 9.06 ± 1.43** 11.45 ± 1.16**# < 0.001
GLP-1 (pmol/L) 1.28 ± 0.35 0.42 ± 0.16** 0.90 ± 0.15*## < 0.001
Cr (μmol/L) 80.90 ± 15.28 92.36 ± 15.07 89.31 ± 8.53 0.229
TC (mmol/L) 1.43 ± 0.29 1.66 ± 0.34 1.73 ± 0.29 0.143
TG (mmol/L) 1.15 ± 0.23 1.21 ± 0.37 1.16 ± 0.27 0.997
LDLc (mmol/L) 0.30 ± 0.14 0.37 ± 0.12 0.35 ± 0.13 0.576
HDLc (mmol/L) 0.44 ± 0.11 0.47 ± 0.07 0.45 ± 0.11 0.827
SOD (U/mL) 476.52 ± 61.76 386.28 ± 52.86** 408.68 ± 28.17* 0.004
hs-CRP (mg/L) 1.49 ± 0.68 6.19 ± 1.63** 3.27 ± 1.04*## < 0.001
MDA (nmol/mL) 9.51 ± 2.00 16.62 ± 2.77** 12.49 ± 2.13## < 0.001
8-OHdG (ng/mL) 1.51 ± 0.50 3.79 ± 0.70** 2.27 ± 0.26*## < 0.001
  1. Values are mean ± SD
  2. INS, insulin; GLP-1, glucagon like peptide-1; Cr, creatinine; TC, total cholesterol; TG, triglyceride; LDLc, low-density lipoprotein cholesterol; HDLc, high-density lipoprotein cholesterol; SOD, superoxide dismutase; hs-CRP, hypertensive C-reactive protein; MDA, malondialdehyde; 8-OHdG, 8-hydroxy-2′-deoxyguanosine
  3. * Compared with CON group, P < 0.05
  4. ** Compared with CON group, P < 0.01
  5. # Compared with DM group, P < 0.05
  6. ## Compared with DM group, P < 0.01