Skip to main content

Table 2 Serum biochemical, oxidative stress and inflammation examination

From: Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits

 

CON group (n = 10)

DM group (n = 10)

DM-A group (n = 10)

P value

Glucose (mmol/L)

4.98 ± 0.45

14.12 ± 1.69**

11.03 ± 2.01**#

< 0.001

INS (mmol/L)

17.84 ± 2.57

9.06 ± 1.43**

11.45 ± 1.16**#

< 0.001

GLP-1 (pmol/L)

1.28 ± 0.35

0.42 ± 0.16**

0.90 ± 0.15*##

< 0.001

Cr (μmol/L)

80.90 ± 15.28

92.36 ± 15.07

89.31 ± 8.53

0.229

TC (mmol/L)

1.43 ± 0.29

1.66 ± 0.34

1.73 ± 0.29

0.143

TG (mmol/L)

1.15 ± 0.23

1.21 ± 0.37

1.16 ± 0.27

0.997

LDLc (mmol/L)

0.30 ± 0.14

0.37 ± 0.12

0.35 ± 0.13

0.576

HDLc (mmol/L)

0.44 ± 0.11

0.47 ± 0.07

0.45 ± 0.11

0.827

SOD (U/mL)

476.52 ± 61.76

386.28 ± 52.86**

408.68 ± 28.17*

0.004

hs-CRP (mg/L)

1.49 ± 0.68

6.19 ± 1.63**

3.27 ± 1.04*##

< 0.001

MDA (nmol/mL)

9.51 ± 2.00

16.62 ± 2.77**

12.49 ± 2.13##

< 0.001

8-OHdG (ng/mL)

1.51 ± 0.50

3.79 ± 0.70**

2.27 ± 0.26*##

< 0.001

  1. Values are mean ± SD
  2. INS, insulin; GLP-1, glucagon like peptide-1; Cr, creatinine; TC, total cholesterol; TG, triglyceride; LDLc, low-density lipoprotein cholesterol; HDLc, high-density lipoprotein cholesterol; SOD, superoxide dismutase; hs-CRP, hypertensive C-reactive protein; MDA, malondialdehyde; 8-OHdG, 8-hydroxy-2′-deoxyguanosine
  3. * Compared with CON group, P < 0.05
  4. ** Compared with CON group, P < 0.01
  5. # Compared with DM group, P < 0.05
  6. ## Compared with DM group, P < 0.01
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840