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Table 1 Hemodynamic and echocardiographic studies

From: Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits

  CON group (n = 10) DM group (n = 10) DM-A group (n = 10) P value
HR (bpm) 281.4 ± 10.2 291.5 ± 11.3 279.8 ± 15.0 0.145
SBP (mmHg) 124.38 ± 5.95 128.99 ± 5.83 128.80 ± 5.49 0.217
DBP (mmHg) 78.03 ± 4.19 81.05 ± 4.72 80.6 ± 5.71 0.428
MBP (mmHg) 95.4 ± 4.53 97.79 ± 9.93 98.55 ± 5.70 0.658
LVEDP (mmHg) 0.18 ± 0.07 2.37 ± 0.57** 1.07 ± 0.30**## < 0.001
+ dp/dtmax (mmHg/m) 3969.02 ± 464.27 3643.68 ± 332.94 3994.28 ± 380.08 0.167
− dp/dtmax (mmHg/m) 2852.58 ± 435.33 1475.75 ± 266.74** 2154.03 ± 391.43**## < 0.001
LAD (mm) 6.25 ± 0.90 8.94 ± 0.88** 7.81 ± 0.60**# < 0.001
IVS (mm) 1.83 ± 0.31 2.75 ± 0.33** 2.27 ± 0.17*## < 0.001
PWLV (mm) 1.71 ± 0.37 2.74 ± 0.32** 2.26 ± 0.19**# < 0.001
LVEDD (mm) 11.92 ± 0.72 12.82 ± 0.97 12.19 ± 0.71 0.097
LVESD (mm) 7.79 ± 0.53 7.58 ± 0.57 7.97 ± 0.64 0.426
LVEF (%) 56.31 ± 2.50 55.94 ± 2.59 56.40 ± 1.76 0.916
RVEDD (mm) 4.61 ± 0.71 4.98 ± 0.55 4.99 ± 0.38 0.325
E/e′ ratio 4.95 ± 1.36 11.73 ± 2.85** 8.89 ± 1.16**# < 0.001
Heart weight ratio (1/1000) 2.58 ± 0.19 2.82 ± 0.11 2.68 ± 0.24 0.054
Body weight (kg) 3.42 ± 0.30 2.72 ± 0.75** 2.95 ± 0.26** < 0.001
  1. Values are mean ± SD
  2. HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; LVEDP, left ventricular end diastolic presssure; + dp/dtmax, maximal increasing rate of left intraventricular pressure; − dp/dtmax, maximal decreasing rate of left intraventricular pressure; LAD, left atrial diameter; IVS, interventricular septal; PWLV, left ventricular posterior wall; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LVEF, left ventricular ejection fraction; RVEDD, right ventricular end-diastolic dimension; E/e′: the ratio of early diastolic filling velocity to the early diastolic mitral annulus velocity
  3. * Compared with CON group, P < 0.05
  4. ** Compared with CON group, P < 0.01
  5. # Compared with DM group, P < 0.05
  6. ## Compared with DM group, P < 0.01