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Table 1 Hemodynamic and echocardiographic studies

From: Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits

 

CON group (n = 10)

DM group (n = 10)

DM-A group (n = 10)

P value

HR (bpm)

281.4 ± 10.2

291.5 ± 11.3

279.8 ± 15.0

0.145

SBP (mmHg)

124.38 ± 5.95

128.99 ± 5.83

128.80 ± 5.49

0.217

DBP (mmHg)

78.03 ± 4.19

81.05 ± 4.72

80.6 ± 5.71

0.428

MBP (mmHg)

95.4 ± 4.53

97.79 ± 9.93

98.55 ± 5.70

0.658

LVEDP (mmHg)

0.18 ± 0.07

2.37 ± 0.57**

1.07 ± 0.30**##

< 0.001

+ dp/dtmax (mmHg/m)

3969.02 ± 464.27

3643.68 ± 332.94

3994.28 ± 380.08

0.167

− dp/dtmax (mmHg/m)

2852.58 ± 435.33

1475.75 ± 266.74**

2154.03 ± 391.43**##

< 0.001

LAD (mm)

6.25 ± 0.90

8.94 ± 0.88**

7.81 ± 0.60**#

< 0.001

IVS (mm)

1.83 ± 0.31

2.75 ± 0.33**

2.27 ± 0.17*##

< 0.001

PWLV (mm)

1.71 ± 0.37

2.74 ± 0.32**

2.26 ± 0.19**#

< 0.001

LVEDD (mm)

11.92 ± 0.72

12.82 ± 0.97

12.19 ± 0.71

0.097

LVESD (mm)

7.79 ± 0.53

7.58 ± 0.57

7.97 ± 0.64

0.426

LVEF (%)

56.31 ± 2.50

55.94 ± 2.59

56.40 ± 1.76

0.916

RVEDD (mm)

4.61 ± 0.71

4.98 ± 0.55

4.99 ± 0.38

0.325

E/e′ ratio

4.95 ± 1.36

11.73 ± 2.85**

8.89 ± 1.16**#

< 0.001

Heart weight ratio (1/1000)

2.58 ± 0.19

2.82 ± 0.11

2.68 ± 0.24

0.054

Body weight (kg)

3.42 ± 0.30

2.72 ± 0.75**

2.95 ± 0.26**

< 0.001

  1. Values are mean ± SD
  2. HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; LVEDP, left ventricular end diastolic presssure; + dp/dtmax, maximal increasing rate of left intraventricular pressure; − dp/dtmax, maximal decreasing rate of left intraventricular pressure; LAD, left atrial diameter; IVS, interventricular septal; PWLV, left ventricular posterior wall; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LVEF, left ventricular ejection fraction; RVEDD, right ventricular end-diastolic dimension; E/e′: the ratio of early diastolic filling velocity to the early diastolic mitral annulus velocity
  3. * Compared with CON group, P < 0.05
  4. ** Compared with CON group, P < 0.01
  5. # Compared with DM group, P < 0.05
  6. ## Compared with DM group, P < 0.01