Mortality cause | Q1 | Q2 | Q3 | Q4 | Q5 | Total |
---|---|---|---|---|---|---|
a. Cause-specific death according to GIT quintiles | ||||||
All-cause, N (%) | 8765 (1.97%) | 6306 (1.31%) | 6188 (1.41%) | 5221 (1.11%) | 4788 (1.09%) | 31,268 |
 Incidence (event/105 person-years) | 108.7 | 71.3 | 73.2 | 60.9 | 60.0 | 74.6 |
Total cardiovascular, N (%) | 1075 (0.24%) | 641 (0.13%) | 624 (0.14%) | 394 (0.08%) | 334 (0.08%) | 3068 |
 Incidence (event/105 person-years) | 13.3 | 7.25 | 7.4 | 4.6 | 4.2 | 7.3 |
Coronary heart disease, N (%) | 526 (0.12%) | 288 (0.06%) | 308 (0.07%) | 165 (0.03%) | 156 (0.04%) | 1443 |
 Incidence (event/105 person-years) | 6.5 | 3.3 | 3.6 | 1.9 | 1.9 | 3.4 |
Stroke, N (%) | 172 (0.04%) | 115 (0.02%) | 110 (0.03%) | 72 (0.02%) | 45 (0.01%) | 514 |
 Incidence (event/105 person-years) | 2.1 | 1.3 | 1.3 | 0.8 | 0.6 | 1.2 |
Diabetes, N (%) | 184 (0.04%) | 98 (0.02%) | 96 (0.02%) | 51 (0.01%) | 28 (0.01%) | 457 |
 Incidence (event/105 person-years) | 2.3 | 1.1 | 1.1 | 0.6 | 0.4 | 1.1 |
Non-CVD, non-diabetes, N (%) | 7506 (1.68%) | 5567 (1.16%) | 5468 (1.24%) | 4776 (1.01%) | 4426 (1.01%) | 27,743 |
 Incidence (event/105 person-years) | 93.1 | 63.0 | 64.7 | 55.7 | 55.4 | 66.2 |
b. Cox proportional hazard models | ||||||
All cause  (unadjusted) | 1.84 (1.78, 1.91) | 1.25 (1.20, 1.29) | 1.21 (1.16, 1.25) | 1.04 (1.00, 1.08) | 1 | 4.10*10−231 |
All cause  (adjusted) | 1.23 (1.17, 1.28) | 1.08 (1.04, 1.13) | 1.04 (1.00, 1.08) | 1.01 (0.98, 1.06) | 1 | 1.3*10−33 |
Total CVD  (unadjusted) | 3.32 (2.93, 3.75) | 1.92 (1.68, 2.19) | 1.71 (1.49, 1.95) | 1.15 (0.99, 1.33) | 1 | 2.13*10−126 |
Total CVD  (adjusted) | 1.76 (1.52, 2.04) | 1.44 (1.24, 1.66) | 1.27 (1.11, 1.46) | 1.05 (0.91, 1.22) | 1 | 1.3*10−14 |
CHD  (unadjusted) | 3.49 (2.92, 4.18) | 1.87 (1.54, 2.27) | 1.8 (1.48, 2.18) | 1.03 (0.83, 1.29) | 1 | 1.21*10−66 |
CHD  (adjusted) | 1.70 (1.37, 2.11) | 1.36 (1.09, 1.68) | 1.31 (1.07, 1.60) | 0.95 (0.76, 1.18) | 1 | 1.6*10−9 |
Stroke  (unadjusted) | 3.96 (2.85, 5.50) | 2.60 (1.84, 3.66) | 2.22 (1.57, 3.15) | 1.56 (1.08, 2.27) | 1 | 5.06*10−24 |
Stroke  (adjusted) | 2.03 (1.39, 2.98) | 1.83 (1.26, 2.66) | 1.61 (1.12, 2.30) | 1.40 (0.96, 2.03) | 1 | 3.3*10−6 |
Diabetes (unadjusted) | 6.96 (4.68, 10.36) | 3.76 (2.47, 5.72) | 3.08 (2.02, 4.69) | 1.81 (1.14, 2.87) | 1 | 5.13*10−38 |
Diabetes  (adjusted) | 3.14 (2.00, 4.94) | 2.36 (1.5, 3.7) | 2.04 (1.32, 3.15) | 1.55 (0.97, 2.46) | 1 | 3.2*10−9 |
Non CVD/diabetes  (unadjusted) | 1.70 (1.64, 1.77) | 1.18 (1.13, 1.23) | 1.16 (1.11, 1.20) | 1.02 (0.98, 1.06) | 1 | 7.78*10−247 |
Non CVD/diabetes  (adjusted) | 1.17 (1.12, 1.22) | 1.04 (1.00, 1.09) | 1.01 (0.97, 1.05) | 1.01 (0.97, 1.05) | 1 | 1.3*10−19 |