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Fig. 7 | Cardiovascular Diabetology

Fig. 7

From: A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Fig. 7

Assessment of oxidative stress status in cardiomyocytes in DAPA or INSU treated MetS rats compared to MetS rats and age-matched controls. Intracellular ROS ([ROS]i) (a) and RNS levels ([RNS]i) (b) imagined with confocal microscopy in cells loaded with either a specific dyes DCFDA or DAF, respectively. Maximal fluorescence intensity was achieved by a HEPES-buffered solution supplemented with H2O2 (100 μM) and NO donor ZipNONO, (100 μM). The free and total protein thiol levels (c) and the ADP/ATP ratio (d) in isolated cardiomyocytes. The total number of cells/group/protocol; n = 15–17. Significance level at *p < 0.05 vs. CON group and #p < 0.05 vs. MetS group

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