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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Fig. 6

Confocal imaging of intracellular levels of free Na+ and H+ and analysis of mitochondrial function in DAPA or INSU treated MetS rats compared to MetS rats and age-matched controls. The level of free Na+ ([Na]i) estimated in cells loaded with Na+-sensitive SBFI florescent dye (a) and free H+ ([H+]i or [pH]i) with SNARF-1AM (b). The mitochondrial membrane potential (MMP, as FCCP responses) in isolated JC-1 loaded cardiomyocytes (c). The expression levels of mitofusion proteins Mfn-1 and Mfn-2 and their ratio (d). The expression level of mitofission protein Fis-1 (e). The total number of cells/group/protocol; n = 10–19. Significance level at *p < 0.05 vs. CON group and #p < 0.05 vs. MetS group

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