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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Fig. 5

Changes in Ca2+ transients in DAPA or INSU treated MetS rats compared to MetS rats and age-matched controls rats in Fura-2AM loaded cardiomyocytes. The basal level of Ca2+ in resting cells (a), the representative original Ca2+ transients under electrical stimulation (b, left), the amplitude of transients Ca2+ changes and their corresponding kinetics under electrical-field stimulation (b, right), the time course of Ca2+-transients (c) in DAPA or INSU treated MetS rats compared to MetS rats and age-matched control rats. d Assessment of sarco(endo)plasmic reticulum (SR) Ca2+ content obtained following 10 mM caffeine applications. The total number of cells/group/protocol; n = 19–30. Significance level at *p < 0.05 vs. CON group and #p < 0.05 vs. MetS group. TP time to peak, DT50 decreasing time to 50% relaxation

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