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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Fig. 3

Effects of DAPA or INSU treatment on action potential parameters in freshly isolated cardiomyocytes. a Representative single cell action potential traces for all groups. b Action potential duration (APD) at 25, 50, 75, 90% (APD25, APD50, APD75, APD90) of repolarization are examined from DAPA or INSU treated MetS group compared to MetS and age-matched controls. The current–voltage relations (current–voltage, I–V, characteristics) of voltage-dependent Na+-channels (c) and L-type Ca2+-channels (d) for all groups. The calculated maximum current of Na+-channels (− 40 mV) and Ca2+-channels (0 mV) are given in the lower parts of the graphs as an inset. The total number of cells/group/protocol; n = 6–7. Significance level at *p < 0.05 vs. CON group and #p < 0.05 vs. MetS group

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